Browsing by Author "Carvalho, Cintia Cristina de"

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    Biological screening of extracts of Brazilian Asteraceae plants.
    (2013) Carvalho, Cintia Cristina de; Machado, Kamilla Nunes; Ferreira, Paulo Michel Pinheiro; Pessoa, Cláudia; Fonseca, Thaisa Helena Silva; Gomes, Maria Aparecida; Nascimento, Andréa Mendes do
    Natural products are a very productive source of leads for the development of medicines. Seven Brazilian Asteraceae adult plants were randomly chosen. The current study was designed to evaluate the antiprotozoal and cytotoxic activities in vitro of 21 extracts obtained. Phytochemical properties of the most active extracts also were checked. Cytotoxic activity was evaluated by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) method against human tumor cell lines (HCT-116, OVCAR 8 and SF-295). The antiprotozoal activity was evaluated against Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia. None of the extracts showed antiprotozoal activity. However, 76% of the extracts displayed moderate to high in vitro cytotoxic activities against human cancer cell which suggests that they are a promising source of anticancer compound, since none of the extracts showed hemolytic activity. Terpenoids, flavonoids, saponins, tannins, besides other compound classes, were identified and may be responsible for their antitumor activity. Cytotoxic assays indicate the anticancer potential of Asteraceae species from Brazil.
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    Chemical composition and antimicrobial activity of essential oil from Brazilian plants Acanthospermum australe, Calea fruticosa and Mikania glauca.
    (2014) Carvalho, Cintia Cristina de; Turatti, Izabel Cristina Casanova; Lopes, Norberto Peporine; Salvador, Marcos José; Nascimento, Andréa Mendes do
    The essential oils of leaves of Acanthospermum australe, Calea fruticosa and Mikania glauca (Asteraceae) from southeastern Brazil were obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS). Oxygenated sesquiterpenes were predominant in C. fruticosa (47.8%) whereas sesquiterpenes hydrocarbons constituents predominated in A. australe (85.1%) and M. glauca (63.3%) oils. Caryophyllene oxide, α-cadinol and selin-11-en-4-α-ol were the most abundant components in C. fruticosa. Germacrene D, (E)-caryophyllene and bicyclogermacrene were the major components observed in the essential oil obtained from the leaves of A. australe and M. glauca. The antimicrobial capacity of the oils was tested. The results showed that the oils have antimicrobial activity against Gram-negative bacteria and Candida glabrata, with minimal inhibitory concentration (MIC) values between 50 and 1000 μg/ml.
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    Chemical composition of the essential oil of Vernonia crotonoides.
    (2013) Carvalho, Cintia Cristina de; Turatti, Izabel Cristina Casanova; Lopes, Norberto Peporine; Nascimento, Andréa Mendes do