Browsing by Author "Domingos, Ana Luiza Gomes"

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    Association between nutritional status, C-reactive protein, adiponectin and HOMA-AD in Brazilian children.
    (2014) Domingos, Ana Luiza Gomes; Coelho, George Luiz Lins Machado; Volp, Ana Carolina Pinheiro; Oliveira, Fernando Luiz Pereira de; Caldas, Ivo Santana; Freitas, Silvia Nascimento de
    Introduction: In children, the presence of obesity is a major risk factor for the occurrence of cardiovascular diseases on the adulthood. Objective: To evaluate the association of anthropometry, body composition, clinical variables and biochemical profile with C-reactive protein and adiponectin levels, and insulin resistance in children in the municipality of Nova Era, Brazil. Methods: Nested case-control study following a crosssectional study. We evaluated 178 children, 57 of them classified as obese and 121 as normal-weight from a population of 1024 schoolchildren 6 to 10 years old: Blood samples were collected after 12-hour fast to obtain serum and plasma. We collected anthropometric and body composition measures, systolic and diastolic blood pressure data. Sexual maturation was assessed according to the stage of sexual development. We performed Student’s t-test, Mann-Whitney U test, Pearson’s correlation, Spearman’s test and multiple linear regression analysis. Independent variables with p < 0.05 were included in the multiple regression model. Residual analysis was performed to assess model validity. Results: Among obese children, C-reactive protein levels were associated with triacylglycerol levels and body fat percentage estimated by skinfold thickness (R2 adjusted = 27.6%, p < 0.001). Adiponectin was associated with HOMA-IR, HOMAAD and body fat percentage estimated by skinfold thickness (R2 adjusted = 75.5%, p < 0.001). HOMA-AD index was associated with HOMA-IR, adiponectin, systolic blood pressure and weight (R2 adjusted = 90.7%, p < 0.001). Conclusion: Significant associations were found between body composition, anthropometry, clinical variables, biochemical profile and adiponectin and C-reactive protein levels and insulin resistance in obese and normal-weight children.
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    Built and social environments and overweight among Brazilian adults from medium-sized city : CUME Project.
    (2022) Domingos, Ana Luiza Gomes; Hermsdorff, Helen Hermana Miranda; Mendes, Larissa Loures; Oliveira, Fernando Luiz Pereira de; Oliveira, Anderson Castro Soares de; Pimenta, Adriano Marçal; Bressan, Josefina
    A cross-sectional study enrolled participants from the CUME project (n = 289) who lived in Viçosa, Brazil. The neighborhood unit adopted was the buffer (200 meters), considering the participant’s residence as central point. We measure the number of public and private facilities inside the buffer as well as violent criminal occurrences. Food establishments were categorized into establishments with predominant sale of natural or minimally processed foods, mixed establishments, and establishments with predominant sale of ultra-processed foods. Those who attended the face-to-face interview filled two scales of perception of the environment. Overall, 33.6% of participants reported overweight. We observed a higher concentration of individuals close to the central region of the city. Access to different establishments, food environments, and criminal occurrences differed between normal-weight and overweight individuals. The groups deferred in the perception of the location of squares, open public spaces, clubs, and soccer fields. The results indicate the association between environmental characteristics and overweight in Brazilian adults.
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    Cohort profile : the cohort of universities of Minas Gerais (CUME).
    (2018) Domingos, Ana Luiza Gomes; Miranda, Aline Elizabeth da Silva; Pimenta, Adriano Marçal; Hermsdorff, Helen Hermana Miranda; Oliveira, Fernando Luiz Pereira de; Santos, Luana Caroline dos; Lopes, Aline Cristine Souza; Martínez González, Miguel Ángel; Bressan, Josefina
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    Fatores associados à adiponectina e proteína c-reativa em crianças de Nova Era-MG.
    (Programa de Pós-Graduação em Saúde e Nutrição. Escola de Nutrição, Universidade Federal de Ouro Preto., 2012) Domingos, Ana Luiza Gomes; Freitas, Silvia Nascimento de; Coelho, George Luiz Lins Machado; Volp, Ana Carolina Pinheiro
    Na faixa etária pediátrica, a presença da obesidade é um importante fator de risco para a ocorrência de doenças cardiovasculares na idade adulta. Estudos sobre biomarcadores inflamatórios e marcadores de risco cardiovasculares são importantes para a detecção precoce de grupos em risco potencial para doenças cardiometabólicas e implementação de ações de prevenção desde a infância. Diante disso, o objetivo deste trabalho foi verificar as associações entre as variáveis antropométricas, de composição corporal, clínicas, bioquímicas, demográficas e as concentrações da proteína C-reativa (PCR) e da adiponectina em crianças de 6 a 10 anos matriculadas na rede pública de ensino de Nova Era-MG. Com a finalidade de descrever o perfil nutricional dos escolares, um estudo transversal foi realizado em 2009 com 1024 crianças na faixa etária entre 6 e 10 anos de idade utilizando o indicador Índice de Massa Corporal por Idade (IMC/I). A partir deste estudo observou-se uma prevalência de 2,3% de baixo peso, 11,2% de sobrepeso e 6,4% de obesidade. Para comporem a amostra, foram selecionadas todas as crianças diagnosticadas com obesidade (n=65), e para cada criança obesa foram selecionadas duas crianças eutróficas (n=130) que pertenciam à mesma escola. Amostras de sangue foram coletadas após 12 horas de jejum para obtenção de soro e plasma. Foi realizada a avaliação antropométrica, composição corporal e a aferição da pressão arterial. A maturação sexual foi avaliada de acordo com os estágios de desenvolvimento sexual propostos por Tanner. Realizou-se o teste T de Student e teste Mann-Whitney U, para comparação dos grupos, testes de correlação de Pearson e Spearman e análise de regressão linear múltipla. Foram incluídas no modelo de regressão as variáveis independentes que apresentaram valor p inferior a 0,05. Para o ajuste do melhor modelo foi avaliado o efeito de multicolinearidade, observações influentes, e a análise de resíduos para testar a validade dos modelos. A amostra final do estudo foi composta de 183 crianças com idade média de 8,15 ± 1,34 anos, sendo 59,02 % (n=108) de crianças do sexo feminino e 40,98 % (n=75) do masculino. A glicemia de jejum (β=0,006, DP=0,003, p=0,032) e o percentual de gordura corporal estimado pelas pregas cutâneas (β=0,013, DP=0,002, p<0,001) apresentaram melhor capacidade de associação com a concentração da PCR (R²ajustado= 0,228). O HOMA-IR (β = 0,161, DP=0,254, p<0,001) e o HOMA-AD (β=-27,3, DP=2,27, p<0,001) apresentaram melhor associação com a concentração da adiponectina (R²ajustado=0,451). Em conclusão, o percentual de gordura corporal estimado pelas pregas cutâneas e a glicemia se associaram com as concentrações da proteína C-reativa em crianças de 6 a 10 anos de Nova Era, assim, devido ao baixo custo de execução de tais medidas recomenda-se sua aplicação na prática clínica para a detecção de crianças em risco cardiometabólico. Já nos diferentes modelos analisados as variáveis antropométricas não apresentaram associação com as concentrações de adiponectina, e somente o HOMA-AD e HOMA-IR entraram no modelo de regressão múltiplo. Assim, observa-se que as equações apresentadas para a adiponectina apresentam pouca aplicabilidade em estudos epidemiológicos em decorrência do custo para as dosagens das covariáveis explicativas.
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    Resistin and visfatin concentrations are related to central obesity and inflammation in Brazilian children.
    (2018) Simões, Natalia Figuerôa; Domingos, Ana Luiza Gomes; Oliveira, Fernando Luiz Pereira de; Caldas, Ivo Santana; Guedes, Mariana Reis; Fajardo, Virgínia Capistrano; Freitas, Silvia Nascimento de
    Background: The evidence that cardiovascular disease begins in childhood and adolescence, especially in the presence of excess weight, is associated with dysfunction on adipokine pro-inflammatory secretion. These affect glucose metabolism and lead to other complications related to insulin resistance and cardiovascular disease. This study assessed the association of anthropometric and metabolic parameters related to obesity, cardiovascular risk, and insulin resistance with concentrations of resistin and visfatin, in children. Methods: A cross-sectional study was developed with 178 children of 6–10 years old enrolled in public city schools. Anthropometric data, composition body, clinical, and biochemical were measured according to standard procedures. We used multiple regression models by stepwise method to evaluate the associations of resistin and visfatin with variables of interest. Results: In healthy weight children, resistin was associated with LDL cholesterol, visfatin, atherogenic index, and waist-to-height ratio, whereas in obese children resistin was associated with visfatin and interaction between conicity index and HOMA-AD. Furthermore, in healthy weight children, visfatin was associated to resistin and triceps skinfold thickness and negatively associated to HOMA-AD, while in obese ones visfatin was associated with waistto- height ratio, atherogenic index, resistin, and interaction between trunk adiposity index and adiponectin and was negatively associated with the HOMA-IR index. Conclusions: Our study shows an association between anthropometric and biochemical variables related to visceral fat and inflammation. These results suggest the resistin and visfatin as good pro-inflammatory markers. In addition, both adipokines are strongly related to central obesity, in children.
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    Ultra-processed food consumption and dietary, lifestyle and social determinants : a path analysis in Brazilian graduates - CUME project.
    (2022) Mattar, Jéssica Bevenuto; Domingos, Ana Luiza Gomes; Hermsdorff, Helen Hermana Miranda; Juvanhol, Leidjaira Lopes; Oliveira, Fernando Luiz Pereira de; Pimenta, Adriano Marçal; Bressan, Josefina
    Objective: To explore the relationship between ultra-processed foods (UPF) con- sumption and dietary, lifestyle and social determinants using pathway analysis in the baseline of the Cohort of Universities of Minas Gerais (CUME project). Design: Cross-sectional study, in which path analysis was used to estimate direct and indirect effects of dietary practices, sleep, time on the computer and profes- sional status on UPF consumption. Setting: Data were collected in 2016, through an online questionnaire composed of sociodemographic, anthropometric, lifestyle and dietary practices questions, and a FFQ. Participants: Baseline participants from the CUME Project (n 2826), adults who graduated from Universidade Federal de Viçosa or Universidade Federal de Minas Gerais, Brazil. Results: Being employed (P = 0·024), the time spent on the computer (P = 0·031) and the frequency of fried food intake (P < 0·001) were positively and directly associated with UPF consumption, whereas the sleep duration (P = 0·007) and the number of meals per d (P < 0·001) were negatively and directly associated with UPF consumption. Indirect effects were observed between being employed, medi- ated by the sleep duration (P = 0·032) and fried food intake (P = 0·005), whereas being a student is mediated by the time on the computer (P = 0·048). Conclusion: The time spent on the computer, sleep duration and fried food con- sumption showed direct effects on UPF consumption. They also acted as mediators on the relationship between professional status and UPF consumption. Besides, the number of meals eaten each day also was directly associated with UPF consumption.