Browsing by Author "Martins Junior, Francisco de Assis Dias"
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Item 10 km running race induces an elevation in the plasma myokine level of nonprofessional runners.(2019) Barbosa, Lucas Soares Marcucci; Martins Junior, Francisco de Assis Dias; Lobo, Lázaro Fernandes; Morais, Mariana Gomes de; Moreira, Janaina Matos; Vieira, Érica Leandro Marciano; Silva, Albená NunesPurpose Acute and chronic physical exercise is believed to have benefcial efects on human health. Exercise is also able to modulate immune function. We hypothesed that exercise is able to induce many benefts for human health by modulating immune functions through the production and release of many myokines. Here, we investigated the efects of a running race on the level of plasmatic myokines. Methods Nine male volunteers took part in this study. Blood samples were obtained before, immediately after and 24 h after the race. Results Participants completed the 10 km running race in 49.85±7.04 min. The levels of IL-6 elevated after exercise (0.94±0.4–2.82±0.3 pg/ml). The IL-15 plasma level was also higher immediately after (0.88±0.25–1.29±0.36 pg/ml), and 24 h after (1.30±1.01 pg/ml), the end of the exercise. Irisin increased only 24 h after exercise (632.60±188.40– 974.70±232.30 pg/ml). FABP3 increased after exercise (829.60±68.93–1306.00±319.10 pg/ml). The plasma levels of BDNF (4719.00±701.80–5557.00±810.30 pg/ml) and Fractalkine increased after exercise (101.2±34.96–134.90±43.62 pg/ ml). The level of FSTL (7265.00±1553.00–9074.00±1662.00 pg/ml) and Osteonectin (16.52±3.54–15.71±3.38 pg/ml) also increased after exercise, and then returned to baseline level 24 h after the end of the session. Conclusion Taken together, these results suggest that a 10 km running race induces elevation of important myokine plasma levels.Item Angiotensin-(1–7) oral formulation improves physical performance in mountain bike athletes : a double‐blinded crossover study.(2021) Moura, Samara Silva de; Mendes, Adália Táci Pereira; Martins Junior, Francisco de Assis Dias; Totou, Nádia Lúcia; Coelho, Daniel Barbosa; Oliveira, Emerson Cruz de; Santos, Daisy Motta; Santos, Robson Augusto Souza dos; Oliveira, Lenice Kappes BeckerBackground: The ECA2/Ang-(1–7)/Mas axis is shown to be involved in effects mediated by physical exercise, as it can induce the release of nitric oxide (ON) and bradykinin (BK), which are potent vasodilators. The vasodilating action the NO/BK can contribute to increased metabolic efficiency in muscle tissue and central nervous system. The formulation HPβ-CD-Ang-(1–7) through its mechanisms of action can be a promising supplement to aid in the maintenance and improvement of performance and may also favor recovery during competitions. The premise of this study was to investigate the effects of acute oral supplementation HPβ-CD-Ang-(1–7) on the performance of mountain bike (MTB) practitioners. Methods: Fourteen recreational athletes, involved in training programs for at least one year, participated in this crossover design study. Subjects underwent two days of testing with a seven-day interval. HPβ-CD-Ang-(1–7) (1.75 mg) and HPβCD-Placebo were provided in capsules three hours prior to tests. To determine the safety of the HPβ-CD-Ang-(1–7) formulation associated with physical effort, cardiovascular parameters heart rate (HR) and blood pressure (BP) were analyzed. Physical performance was measured using maximal oxygen uptake (VO2), total exercise time (TET), mechanical work (MW), mechanical efficiency (ME), and rating of perceived exertion (RPE). Respiratory exchange coefficient (REC), lactate and non-esterified fatty acids (NEFAs) were measured. Maximal incremental tests were performed on a progressively loaded leg cycle ergometer. Results: There were no significant differences in terms of HR or BP at rest and maximum effort between the HPβ-CD-Ang- (1–7) and placebo groups. The VO2max showed significant differences (p = 0.04). It was higher in the Ang-(1–7)condition (66.15 mlO2.kg− 1 .min− 1 ) compared to the placebo (60.72 mlO2.kg− 1 .min− 1 ). This was also observed for TET (Ang-(1–7) 39.10 min vs. placebo 38.14 min; p = 0.04), MW (Ang-(1–7) 156.7 vs. placebo 148.2; p = 0.04), and at the lowest RPE (Ang-(1–7) vs. placebo; p = 0.009). No significant differences were observed for REC, NEFAs, or Lactate. Conclusions: These results suggest that HPβ-CD-Ang-(1–7) improves the physical performance of MTB recreational athletes and could be a promising supplement. Trial registration: RBR-2 × 56pw8, registered January 15th, 2021. The study was prospectively registered.Item A single bout of fatiguing aerobic exercise induces similar pronounced immunological responses in both sexes.(2022) Lobo, Lázaro Fernandes; Morais, Mariana Gomes de; Barbosa, Lucas Soares Marcucci; Martins Junior, Francisco de Assis Dias; Avelar, Luíza Martino; Vieira, Erica Leandro Marciano; Martins, Felipe José Aidar; Wanner, Samuel Penna; Silva, Lucélia Scarabeli; Noman, Maria Clara; Camargos, Bruno Muzzi; Freitas, Kátia Michelle; Gonçalves, William Antonio; Pinho, Vanessa; Silva, Albená Nunes daIntroduction: Physical exercise can acutely and chronically modulate immunological responses. Women and men have different innate and adaptive immune responses, and in this sense, these two groups may also have different acute immunological responses induced by exercise. In addition, it is essential to understand further whether the effects of physical exercise on the immune system responses depend on sex because limited scientific evidence on this topic is available. This information may allow athletes and coaches to improve the training process, mainly to understand if the physiological impact of given training stimuli in women is similar to that in men. Objective: The present study aimed to investigate the acute effects of continuous submaximal exercise until fatigue on physiological and immunological parameters in amateur female and male runners. Methods: This study included 18 female and 15 male volunteers. Each participant visited the laboratory on four consecutive days. The first visit consisted of medical history taking and explaining the study design. On the second visit, the participants were subjected to an incremental test to determine their maximal rate of oxygen consumption (VO2max) that was required to prescribe the intensity of the submaximal exercise protocol. On the third visit, the fatiguing exercise protocol was performed at 77%–80% of the VO2max. During this submaximal exercise, the heart rate, rating of perceived exertion (RPE), and blood lactate were recorded. Blood samples were collected before, immediately after, and 1 h after the fatiguing protocol to analyze the plasma levels of cytokines and creatine kinase (CK) and to count leukocytes. Finally, on the fourth visit, the participants underwent physical evaluations to measure their body composition using dual-energy X-ray absorptiometry (DXA) imaging. Results: The average ages of the female and male groups were 34.2 ± 3.7 and 30.5 ± 4.3 years old, respectively. The female group ran 57 ± 27 min, while the male group ran 52 ± 15 min before fatiguing. In the female group, when comparing before and after the submaximal exercise, marked increases were observed in the following variables: heart rate (from 68.5 to 180.4 bpm), RPE (from 3.6 to 8.2), lactate (from 2.1 to 4.49 mmol/L), and CK (from 89.5 to 126.3 U/L). In addition, the female group showed an increased number of total leukocytes (from 7222.3 to 11162.9 × 106 /μl), neutrophils (from 4,403 to 6,480 × 106 /μl), and lymphocytes (from 2,342 ± to 3,562 × 106 /μl) from pre- to post-submaximal exercise. In the male group, similar elevations in psychophysiological variables were observed, as evidenced by comparing the heart rate (from 52.8 to 184.1 bpm), RPE (from 0.0 to 8.9), lactate (from 2.7 to 7.2 mmol/L), and CK (from 106.2 to 165 U/L) before and after the submaximal exercise. The male group also showed an augmented number of total leukocytes (from 6,245 to 8,050 × 106 /μl), neutrophils (from 3,335 to 4,128 × 106 /), and lymphocytes (from 2,191 to 3,212 × 106 /μl) when comparing pre- and post-submaximal exercise. There were no differences in the changes between women and men for these parameters. Conclusion: The aerobically fatiguing exercise protocol induced pronounced changes in the heart rate, plasma levels of lactate and CK, total leukocyte count, especially the number of neutrophils and lymphocytes, in both sexes. The fatiguing exercise protocol also changed the plasma levels of IL-6 and IL-10 in the female and male groups. Under the present conditions, the physiological changes induced by fatiguing submaximal exercise, including the immunological changes, were not influenced by sex. This study shows that the same aerobic physical exercise can alter immunological parameters in women and men, and this response is similar between sexes.Item Swimming training improves cardiovascular autonomic dysfunctions and prevents renal damage in rats fed a high-sodium diet from weaning.(2020) Souza, Jaqueline Aparecida de; Oliveira, Lenice Kappes Becker; Batista, Marcos Adriano Carlos; Braga, Daiane Cristina de Assis; Gomes, Paula Magalhães; Alzamora, Andréia Carvalho; Vieira, Maria Aparecida Ribeiro; Lima, Wanderson Geraldo de; Andrade, Marina Gonçalves Caetano; Sanches, Bruno de Lima; Totou, Nádia Lúcia; Martins Junior, Francisco de Assis Dias; Oliveira, Lisandra Brandino de; Antunes, Vagner Roberto; Cardoso, Leonardo MáximoHigh sodium intake is an important factor associated with hypertension. High-sodium intake with exercise training can modify homeostatic hydro-electrolytic balance, but the effects of this association are mostly unknown. In this study, we sought to investigate the effects of swimming training (ST) on cerebrospinal fluid (CSF) Na+ concentration, sympathetic drive, blood pressure (BP) and renal function of rats fed a 0.9% Na+ (equivalent to 2% NaCl) diet with free access to water for 22 weeks after weaning. Male Wistar rats were assigned to two cohorts: (1) fed standard diet (SD) and (2) fed high-sodium (HS) diet. Each cohort was further divided into trained and sedentary groups. ST normalised BP levels of HS rats as well as the higher sympathetically related pressor activity assessed by pharmacological blockade of ganglionic transmission (hexamethonium). ST preserved the renal function and attenuated the glomerular shrinkage elicited by HS. No change in blood volume was found among the groups. CSF [Na+] levels were higher in sedentary HS rats but were reduced by ST. Our findings showed that ST effectively normalised BP of HS rats, independent of its effects on hydro-electrolytic balance, which might involve neurogenic mechanisms regulated by Na+ levels in the CSF as well as renal protection.Item The curcumin supplementation with piperine can influence the acute elevation of exercise-induced cytokines : double-blind crossover study.(2022) Castro, Stéfani Miranda; Martins, Felipe José Aidar; Moura, Samara Silva de; Barbosa, Lucas Soares Marcucci; Lobo, Lázaro Fernandes; Martins Junior, Francisco de Assis Dias; Silva Filha, Roberta da; Castro, Pedro Alves Soares Vaz de; Silva, Ana Cristina Simões e; Souza, Danielle da Glória de; Silva, Siomara Aparecida da; Pinto, Kelerson Mauro de Castro; Costa, Guilherme de Paula; Silva, Ana Filipa; Clemente, Filipe Manuel; Pereira, William Valadares Campos; Silva, Albená Nunes daBackground: to evaluate the effects of one week of supplementation with curcumin combined with piperine on physical performance, immune system cell counts, muscle damage, and plasma levels of inflammatory markers after a treadmill running training session. Methods: This study is a double-blind, crossover-balanced clinical trial with a three-week intervention. Sixteen male runners with a mean age of 36 ± 9 years and VO2 max of 60.6 ± 9.03 mL.kg −1 min −1 were recruited and randomly divided into 2 groups: the first group (CPG) was supplemented daily for 7 days with 500 mg of curcumin + 20 mg piperine, and the second group (PG) was supplemented with 540 mg of cellulose. After the 7th day of supplementation, the volunteers participated in the experimental running protocol, where blood samples were collected before, after, and one hour after exercise for analysis of the number of leukocytes, creatine kinase, and cytokine concentration (IL-2, TNF-α, IFN, IL-6, and IL-10) using flow cytometry. This process was repeated, reversing the supplementation offered to the groups. Results: curcumin and piperine supplementation could not change the physical performance, immune cell counts, and muscle damage; however, the aerobic fatiguing exercise protocol inhibited the elevation of the plasmatic levels of some cytokines. The running exercise protocol could elevate the circulating levels of IL-2 (from 49.7 to 59.3 pg/mL), TNF-α (from 48.5 to 51.5 pg/mL), INF (from 128.8 to 165.0 pg/mL), IL-6 (from 63.1 to 77.3 pg/mL), and IL-10 (from 48.9 to 59.6 pg/mL) 1 h after the end of the running protocol. However, the curcumin and piperine supplementation could inhibit this elevation. Conclusions: curcumin and piperine supplementation had no effect on physical performance, immune cell counts, or muscle damage; however, the supplementationItem The effects of aquatic and land exercise on resting blood pressure and post-exercise hypotension response in elderly hypertensives.(2019) Martins Junior, Francisco de Assis Dias; Gomes, Samuel Gamarano; Silva, Fernando Ferreira da; Souza, Perciliany Martins de; Oliveira, Emerson Cruz de; Coelho, Daniel Barbosa; Nascimento Neto, Raimundo Marques do; Lima, Wanderson Geraldo de; Oliveira, Lenice Kappes BeckerObjective: This study compared resting blood pressure (BP) using ambulatory BP monitoring (ABPM) responses in two groups of subjects trained in land exercise (LE) and aquatic exercise (AE), and assessed post-exercise hypotension (PEH) using ABPM, after land- and aquatic-based exercises. Methods: ABPM (24 hours) was used to measure the baseline BP in elderly hypertensive women trained in LE and AE and the PEH induced by exercise. For this, 40 subjects were evaluated at rest and after a land- or aquatic-based exercise session (aerobic: 75% of reserve heart rate combined with resistance exercise). Results: The daytime BP was lower for AE [systolic BP (SBP) 124 ± 1.0 mmHg, diastolic BP (DBP) 70 ± 1.5 mmHg] than for LE (SBP 134 ± 0.9 mmHg, DBP 76 ± 0.9 mmHg), but there were no differences at night-time. The aquatic exerciseinduced PEH in the second hour was maintained at the 24th hour post-exercise. For land exercise-induced PEH, it was maintained at the 12th hour post-exercise. The SBP and DBP were lower at the 24th hour for AE than for LE. Conclusion: Elderly hypertensive people trained in AE had lower baseline BP during the daytime. SBP and DBP values were lower for individuals trained in AE, and their PEH was more rapid and longer lasting after AE.Item The effects of strength training session with different types of muscle action on white blood cells counting and Th1/Th2 response.(2019) Barbosa, Lucas Soares Marcucci; Martins Junior, Francisco de Assis Dias; Lobo, Lázaro Fernandes; Morais, Mariana Gomes de; Martins, Felipe José Aidar; Vieira, Erica Leandro Marciano; Silva, Albená Nunes daAim This research investigated the effects of a strength training session with two different types of muscle actions, predominantly concentric or eccentric in the physiological variables, including the counting of white blood cells and inflammatory mediators; and consequently, changes in the Th1/Th2 balance. Methods Twelve healthy adult men performed a strength training session, using two different protocols: predominantly concentric with 5 s of the concentric phase by 1 s of the eccentric phase, and a predominantly eccentric with 1 s of the concentric phase by 5 s of the eccentric phase. Blood samples were collected, before, immediately after and 2 h after the end of the session to analyze subpopulations of white blood cells, creatine kinase (CK), irisin and the levels of anti- and pro-inflammatory mediators. Results Both strength training protocols were able to increase the heart rate, lactate concentration, rate of perceived exertion and the levels of circulating creatine kinase. The predominantly concentric strength training exercises increased the number of total white blood cells, and neutrophils 2 h after the end of the session. The plasmatic levels of interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), interferon-γ (INF-γ), irisin, soluble tumor necrosis factor receptor-1 (sTNFR1) and sTNFR2 did not change after the strength training protocols. Conclusion Therefore, the present study demonstrates that a strength training session is able to disturb the body homeostasis.Item The impact of measures recommended by the government to limit the spread of coronavirus (COVID-19) on physical activity levels, quality of life, and mental health of Brazilians.(2020) Matos, Dihogo Gama de; Martins, Felipe José Aidar; Almeida Neto, Paulo Francisco de; Moreira, Osvaldo Costa; Souza, Raphael Fabrício de; Marçal, Anderson Carlos; Barbosa, Lucas Soares Marcucci; Martins Junior, Francisco de Assis Dias; Lobo, Lázaro Fernandes; Santos, Jymmys Lopes dos; Guerra, Ialuska; Silva, Anselmo de Athayde Costa e; Neves, Eduardo Borba; Cabral, Breno Guilherme de Araújo Tinôco; Reis, Victor Machado; Silva, Albená Nunes daTo reduce transmission of the coronavirus, the Brazilian government adopted containment measures to control the virus’ spread, including limitations to the practice of physical activity. It was aimed to analyze the effects of COVID-19 quarantine on physical activity levels, energy expenditure, quality of life, and level of stress in a sample of the Brazilian population. The sample included 426 participants (7 to 80 years). The International Physical Activity Questionnaire, Short form survey-36 (SF-36), and Stress Perception Scale, were used to assess the level of physical activity, quality of life and stress, respectively. The anthropometric data was used to the assessment of body mass index and basal metabolic rate. Body weight increased significantly in all sample (p < 0.05). During the pandemic, 84% of the sample indicated a low level of physical activity. Furthermore, weekly energy expenditure decreased significantly in all age groups during the pandemic (children p < 0.0001; adolescents: p < 0.0001; adults p < 0.001, and elderly p < 0.0001). All aspects of quality of life, significantly reduced in both sexes in all age groups (p < 0.05). With the exception of children, stress levels increased significantly during the pandemic (adolescents: male: p = 0.003, female: p < 0.05; adults: male: p = 0.003, female: p = 0.01, and elderly: male: p = 0.02, female: p = 0.03). Findings from the present study suggests that COVID-19 social isolation has negatively affected Brazilian’ physical activity and quality of life.Item Use of diuretics is associated with higher risk of sarcopenia in older adults with hypertension.(2022) Martins Junior, Francisco de Assis Dias; Mateo, Dahany Pamela Acta; Silva, Fábio Junior de Miranda; Moura, Samara Silva de; Oliveira, Emerson Cruz; Coelho, Daniel Barbosa; Bearzoti, Eduardo; Pinto, Kelerson Mauro de Castro; Oliveira, Lenice Kappes BeckerBackground: Sarcopenia is a disease that involves skeletal muscle mass loss and is highly prevalent in the older adult population. Moreover, the incidence of sarcopenia is increased in patients with hypertension. Objective: The study aimed to evaluate the association between the classes of the drugs used for arterial hypertension treatment and the presence or absence of sarcopenia. Methods: 129 older adults with hypertension were evaluated by the researchers who registered the participants medication for arterial hypertension treatment. Sarcopenia level was measured by anthropometric parameters, muscular strength, and functional capacity. The data were analyzed by one-way ANOVA followed by post-hoc test and Fisher’s exact test; statistical significance was set at 0.05. Results: Age was not different between women with different levels of sarcopenia, but significant differences were observed between men with absent sarcopenia (66.8±4.2 years) and men with probable sarcopenia (77.0±10.2 years). Individuals with absent sarcopenia showed higher handgrip strength (men: 33.8±7.4, women: 23.2±4.6 Kgf) in comparison with those with sarcopenia (men with probable sarcopenia: 9.5±3.3 Kgf, women with probable, confirmed, and severe sarcopenia: 11.7±2.5, 12.2±3.0, 11.8±1.8 Kgf, respectively). The analysis showed an association between the type of medication and degree of sarcopenia; diuretics were significantly associated with probable sarcopenia, and angiotensin II receptor blockers (alone or in combination with diuretics) was associated with absence of sarcopenia. Conclusions: In conclusion, handgrip strength was a good method to diagnose sarcopenia, and diuretics were associated with increased risk of sarcopenia in older adults with hypertension.