Browsing by Author "Seregheti, Thatiane M. Q."

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    Antiproliferative and photoprotective activities of the extracts and compounds from Calea fruticosa.
    (2020) Seregheti, Thatiane M. Q.; Pinto, Ana Paula Resende Seibert; Gonçalves, Marlucy da Cru; Antunes, Amanda dos Santos; Almeida, Wanessa Aparecida da Silveira; Machado, Ranyelison Silva; Silva, Jurandy N.; Ferreira, Paulo Michel Pinheiro; Pessoa, Claudia; Santos, Viviane Martins Rebello dos; Nascimento, Andréa Mendes do
    In this paper, we complement our previous study on the antiproliferative activity of Calea fruticosa (Asteraceae) by isolating the compounds apigenin-4’,7-dimethyl ether (1), budlein A (2), quercetin (3), and cichoriin (4) from the plant’s aerial parts. The antiproliferative activity of these compounds was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method against human tumor cell lines. Compound 3 displayed moderate antiproliferative activity in three cell lines (HCT 116, PC-3, and SF-295, with cell growth inhibition values of 72.97, 74.55, and 68.94%) and high antiproliferative activity (90.86%) in the HL-60 cell line. The in vitro sun protection factor (SPF) of the extracts and compound 4, with and without sunscreen, was determined by a spectrophotometric method. The ethanol extract exhibited the highest SPF (9.67) at a concentration of 0.100 mg/mL, while compound 4, isolated from this extract, showed a SPF of 13.79 at the same concentration. A relative increased efficacy of SPF was observed for the extracts and compound 4 when sunscreen was also used. Compound 4 has not been reported previously from any species within the genus Calea. Compounds 1–4 were obtained from this species for the first time.