Browsing by Author "Silva, Grazielle Caroline da"

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    ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz.
    (2010) Lucas Filho, Milton Dayrell; Silva, Grazielle Caroline da; Côrtes, Steyner de França; Guia, Thiago Rennó dos Mares; Ferraz, Vany Perpetua; Serra, Carla Penido; Braga, Fernão Castro
    Erythroxylum species have several traditional uses in different countries, including the treatment of hypertension. The ethanol extract from E. gonocladum aerial parts, a species endemic to the Brazilian cerrado, elicited a concentration-dependent inhibition of angiotensin converting enzyme (ACE) (pIC50=4.53±0.05). Extract fractionation led to the isolation of two compounds, whose structures were assigned by spectrometric data as astilbin and β-sitosterol, along with a mixture of palmitic, stearic and linolenic acids. This is the first report on the occurrence of these compounds on E. gonocladum. Astilbin promoted significant ACE inhibition in vitro (pIC50=5.86±0.33) and its activity did not differ from captopril, when both compounds were assayed at 10 μM concentration.