Browsing by Author "Turatti, Izabel Cristina Casanova"

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    Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum.
    (2012) Nascimento, Andréa Mendes do; Conti, Raphael; Turatti, Izabel Cristina Casanova; Cavalcanti, Bruno Coêlho; Lotufo, Leticia Veras Costa; Pessoa, Cláudia; Moraes Filho, Manoel Odorico de; Manfrim, Viviane; Toledo, Juliano Simões de; Cruz, Angela Kaysel; Pupo, Mônica Tallarico
    Ethyl acetate extracts of cultures grown in liquid Czapek and on solid rice media of the fungal endophyte Fusarium oxysporum SS46 isolated from the medicinal plant Smallanthus sonchifolius (Poepp.) H. Rob., Asteraceae, exhibited considerable cytotoxic activity when tested in vitro against human cancer cells. Chromatographic separation yielded anhydrofusarubin (1) and beauvericin (2) that were identified based on their 1H and 13C NMR data. Compounds 1 and 2 showed the strongest cytotoxic activity against different cancer cell lines. Compound 2 also showed promising activity against Leishmania braziliensis. Hexanic extract of F. oxysporum SS50 grown on solid rice media also afforded a mixture of compounds that displayed cytotoxic activity against different cancer cell lines. Chemical analysis of the mixture of compounds, investigated by gas chromatography-mass spectrometry (GC-MS), showed that there was a predominance of methyl esters of fatty acids and alkanes.
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    Chemical composition and antimicrobial activity of essential oil from Brazilian plants Acanthospermum australe, Calea fruticosa and Mikania glauca.
    (2014) Carvalho, Cintia Cristina de; Turatti, Izabel Cristina Casanova; Lopes, Norberto Peporine; Salvador, Marcos José; Nascimento, Andréa Mendes do
    The essential oils of leaves of Acanthospermum australe, Calea fruticosa and Mikania glauca (Asteraceae) from southeastern Brazil were obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS). Oxygenated sesquiterpenes were predominant in C. fruticosa (47.8%) whereas sesquiterpenes hydrocarbons constituents predominated in A. australe (85.1%) and M. glauca (63.3%) oils. Caryophyllene oxide, α-cadinol and selin-11-en-4-α-ol were the most abundant components in C. fruticosa. Germacrene D, (E)-caryophyllene and bicyclogermacrene were the major components observed in the essential oil obtained from the leaves of A. australe and M. glauca. The antimicrobial capacity of the oils was tested. The results showed that the oils have antimicrobial activity against Gram-negative bacteria and Candida glabrata, with minimal inhibitory concentration (MIC) values between 50 and 1000 μg/ml.
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    Chemical composition of the essential oil of Vernonia crotonoides.
    (2013) Carvalho, Cintia Cristina de; Turatti, Izabel Cristina Casanova; Lopes, Norberto Peporine; Nascimento, Andréa Mendes do