Browsing by Author "Zulet, Maria Angeles"

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    Contribution of gender and body fat distribution to inflammatory marker concentrations in apparently healthy young adults.
    (2012) Hermsdorff, Helen Hermana Miranda; Volp, Ana Carolina Pinheiro; Puchau, Blanca; Barbosa, Kiriaque Barra Ferreira; Zulet, Maria Angeles; Bressan, Josefina; Martínez, José Alfredo
    This cross-sectional study assessed the potential contribution of gender, body fat distribution, and their interactions to some inflammatory marker concentrations [C-reactive protein (CRP), complement factor 3 (C3), and ceruloplasmin (Cp)] in young adults.
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    Dietary total antioxidant capacity is inversely related to central adiposity as well as to metabolic and oxidative stress markers in healthy young adults.
    (2011) Hermsdorff, Helen Hermana Miranda; Puchau, Blanca; Volp, Ana Carolina Pinheiro; Barbosa, Kiriaque Barra Ferreira; Bressan, Josefina; Zulet, Maria Angeles; Martínez, José Alfredo
    Background: Dietary total antioxidant capacity (TAC) has been assumed as a useful tool to assess the relationship between the cumulative antioxidant food capacity and several chronic disorders. The aim of this cross-sectional study was to investigate the potential relationships of dietary TAC with adiposity, metabolic and oxidative stress markers in healthy young adults. Methods: This study enrolled 266 healthy subjects (105 men/ 161 women; 22 ± 3 years-old; 22.0 ± 2.7 kg/m2). Dietary intake, anthropometry, blood pressure, lifestyle features, and biochemical data were assessed with validated procedures. Results: In linear regression analyses, dietary TAC values were inversely associated with glycemia, total cholesterol: HDL-c ratio, triglycerides and oxidized-LDL concentrations, and positively associated with HDL-c concentrations, independently of gender, age, smoking status, physical activity, vitamin use supplement, waist circumference, energy intake, fatty acid intake. In addition, plasma TAC was negatively correlated with ox-LDL concentrations (r= -0.20, P = 0.003), independently of the assessed confounding variables. Finally, dietary TAC values were inversely related to waist circumference values (r= -0.17, P = 0.005) as well as to lower mild central obesity occurrence (waist circumference ≥ 80/ 94 cm for women/ men, respectively). Conclusion: Dietary TAC values are inversely associated with glucose and lipid biomarkers as well as with central adiposity measurements in healthy young adults, indicating dietary TAC as a useful tool to assess the health benefits of cumulative antioxidant capacity from food intake. In addition, the independent and inverse relationships of ox-LDL concentrations with dietary and plasma TAC respectively suggest a putative role of antioxidant rich-diet in the link between redox state and atherogenesis at early stage.
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    Efeitos antioxidantes do selênio e seu elo com a inflamação e síndrome metabólica.
    (2010) Volp, Ana Carolina Pinheiro; Bressan, Josefina; Hermsdorff, Helen Hermana Miranda; Zulet, Maria Angeles; Martínez, José Alfredo
    O estado inflamatório crônico e de baixo grau bem como o estresse oxidativo associados à síndrome metabólica são fatores de risco relevantes para o desenvolvimento de doenças cardiovasculares. Neste contexto, o selênio é um mineral essencial que se encontra associado com o correto funcionamento dos principais processos metabólicos celulares. Estudos in vitro e in vivo em modelos experimentais de síndrome metabólica, bem como em humanos, tem investigado o efeito do selênio sobre a expressão e secreção de biomarcadores de inflamação e de estresse oxidativo. Para obtenção dos artigos sobre efeitos antioxidantes do selênio foram feitas pesquisas nos websites científicos. Na literatura encontramos numerosos artigos sobre os diferentes parâmetros modulados pelas concentrações plasmáticas de selênio, incluindo a proteína-C reativa, a interleucina-6, o fator de necrose tumoral-, a interleucina-1e a proteína transportadora de retinol-4. Esta revisão teve por objetivo discutir o papel do selênio nos processos inflamatórios e de estresse oxidativo, associados à síndrome metabólica.
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    Gender-specific relationships between plasma oxidized low-density lipoprotein cholesterol, total antioxidant capacity, and central adiposity indicators.
    (2014) Hermsdorff, Helen Hermana Miranda; Barbosa, Kiriaque Barra Ferreira; Volp, Ana Carolina Pinheiro; Puchau, Blanca; Bressan, Josefina; Zulet, Maria Angeles; Martínez, José Alfredo
    Oxidative stress has a pivotal role in the onset of obesity-related chronic diseases. This study assessed potential gender differences in the associations of adiposity (total vs. central) with oxidative stress markers in healthy young adults.
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    Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects.
    (2016) Carraro, Júlia Cristina Cardoso; Hermsdorff, Helen Hermana Miranda; Mansego, Maria Luisa; Zulet, Maria Angeles; Milagro, Fermín Ignacio; Bressan, Josefina; Martínez, J. Alfredo
    Background/Aim: This study hypothesized an association between healthy dietary patterns, hypermethylation of the tumor necrosis factor-α (TNF-α) promoter and decreased risk of metabolic changes. Methods: Forty normal-weight young women were involved in this crosssectional study. DNA was isolated from white blood cells, and CpG site methylation in TNF-α was analyzed by Sequenom EpiTyper. The quality of the diet was assessed by Healthy Eating Index (HEI-2005). Results: Contradicting our hypothesis, HEI-2005 score was negatively associated with CpG5 (r = –0.460, p = 0.003) and TNF-α total methylation (r = –0.355, p = 0.026). A higher intake of fruits was related to lower insulin, HOMA-IR, and TNF-α methylation. No other dietary pattern was related to TNF-α methylation. TNF-α total methylation correlated positively with systolic blood pressure (r = 0.323; p = 0.042) and CpG5 methylation with body mass index (r = 0.333, p = 0.036). Furthermore, fiber intake was negatively associated with the CpG5 (r = –0.324, p = 0.041) and TNF-α total methylation (r = –0.434, p = 0.005), whereas vitamin C intake was negatively associated with TNF-α total methylation (r = –0.411, p = 0.009). Intakes of apples and citrus fruits were negatively associated with TNF-α total methylation. Conclusion: A healthy dietary pattern and higher fruit intake (particularly apples and citrus fruits) were related to better glucose tolerance in healthy subjects, which could be mediated by lower TNF-α methylation.
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    Interleukin-6 is a better metabolic biomarker than interleukin-18 in young healthy adults.
    (2015) Carraro, Júlia Cristina Cardoso; Hermsdorff, Helen Hermana Miranda; Puchau, Blanca; Zulet, Maria Angeles; Milagro, Fermín Ignacio; Martínez, J. Alfredo
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    Low energy and carbohydrate intake associated with higher total antioxidant capacity in apparently healthy adults.
    (2014) Barbosa, Kiriaque Barra Ferreira; Volp, Ana Carolina Pinheiro; Rocha, José Luiz Marques; Ribeiro, Sônia Machado Rocha; Navarro Blasco, Iñigo; Zulet, Maria Angeles; Martínez, José Alfredo; Bressan, Josefina
    Objectives: The aim of this study was to investigate the associations between plasma total antioxidant capacity (TAC) and anthropometric, biochemical, clinical, and dietary measurements in young and apparently healthy individuals. Methods: We evaluated 156 individuals (91 women and 65 men; ages 23.1 _ 3.5 y; body mass index 22 _ 2.9 kg/m2) for anthropometrics, biochemical markers, clinical, dietary, and some components of the antioxidant defense system, including the plasma TAC. Statistical analyses were performed to detect differences between individuals with TAC higher and lower than the mean value and to screen the associations between TAC and variables of interest. A linear regression model was fitted to identify TAC predictors. Results: Daily caloric intake and macronutrient consumption were lower in individuals who exhibited the highest TAC values (P < 0.05). Linear regression analysis showed that daily calories and carbohydrate intake was a possible negative TAC predictor (P < 0.05). Nevertheless, there was no difference in the values of oxidized low-density lipoprotein in the individuals separated by means of TAC. In contrast, individuals whose plasma TAC values were above the mean showed higher low-density lipoprotein cholesterol concentrations, total cholesterol/high-density lipoprotein cholesterol values, and selenium in nails (P < 0.05). Conclusions: In physiological conditions, the caloric intake level seems to be an important factor to act in the modulation of plasma TAC, before establishing anthropometric impairments of body or metabolic composition, or both. Additionally, the plasma TAC increase may be able to act as a compensatory mechanism.
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    Relationship of oxidized low density lipoprotein with lipid profile and oxidative stress markers in healthy young adults : a translational study.
    (2011) Barbosa, Kiriaque Barra Ferreira; Volp, Ana Carolina Pinheiro; Hermsdorff, Helen Hermana Miranda; Blasco, Iñigo Navarro; Zulet, Maria Angeles; Martínez, José Alfredo; Bressan, Josefina
    Background: Despite oxidized low density lipoprotein (ox-LDL) plays important roles in the pro-inflammatory and atherosclerotic processes, the relationships with metabolic and oxidative stress biomarkers have been only scarcely investigated in young adult people. Thus, the aim of this study was to assess plasma ox-LDL concentrations and the potential association with oxidative stress markers as well as with anthropometric and metabolic features in healthy young adults. Methods: This study enrolled 160 healthy subjects (92 women/68 men; 23 ± 4 y; 22.0 ± 2.9 kg/m2). Anthropometry, body composition, blood pressure, lifestyle features, biochemical data, and oxidative stress markers were assessed with validated tools. Selenium, copper, and zinc nail concentrations were measured by atomic absorption spectrophotometry. Results: Total cholesterol (TC), LDL-c and uric acid concentrations, TC-to-HDL-c ratio, and glutathione peroxidase (GPx) activity were positive predictors of ox-LDL concentrations, while nail selenium level (NSL) was a negative predictor, independently of gender, age, smoking status, physical activity. Those individuals included in the highest tertile of GPx activity (≥611 nmol/[mL/min]) and of NSL (≥430 ng/g of nail) had higher and lower ox-LDL concentrations, respectively, independently of the same covariates plus truncal fat or body mass index, and total cholesterol or LDL-c concentrations. Conclusions: Ox-LDL concentrations were significantly associated with lipid biomarkers, GPx activity, uric acid concentration, and NSL, independently of different assayed covariates, in young healthy adults. These findings jointly suggest the early and complex relationship between lipid profile and redox status balance.
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    Vitamin C and fibre consumption from fruits and vegetables improves oxidative stress markers in healthy young adults.
    (2011) Hermsdorff, Helen Hermana Miranda; Barbosa, Kiriaque Barra Ferreira; Volp, Ana Carolina Pinheiro; Puchau, Blanca; Bressan, Josefina; Zulet, Maria Angeles; Martínez, José Alfredo
    The aim of the present cross-sectional study was to assess the potential relationships between fruit and vegetable (FV) consumption and some oxidative stress markers in young adults, with particular emphasis on fibre and vitamin C intake. The study enrolled 246 healthy subjects (eighty-eight men and 158 women), with a mean age of 22 (SD 3) years and a mean BMI of 21·9 (SD 2·8) kg/m2. Dietary intake, anthropometry, blood pressure, lifestyle features and blood biochemical data were assessed with validated procedures. Those subjects in the highest tertile (T) of FV consumption ($705 g/d) had statistically lower oxidised LDL (ox-LDL) concentrations as well as higher plasma total antioxidant capacity (TAC) and glutathione peroxidase (GPx) activity (P for trend ,0·05), after adjusting for sex, age, energy intake, physical activity, smoking, BMI, vitamin supplement use and other confounding factors. Moreover, plasma ox-LDL concentrations showed a decreasing trend and TAC an increasing trend across tertiles of fibre (T3: $14 g/d) and vitamin C (T3: $150 mg/d) from FV intake, while GPx activity was positively associated with vitamin C intake (P for trend ,0·05). In conclusion, greater FV consumption was independently associated with reduced ox-LDL as well as increased TAC and GPx activity in healthy young adults, with dietary fibre and vitamin C from FV clearly being implicated in this beneficial relationship.