Ru(II)-naphthoquinone complexes with high selectivity for triple negative breast cancer.

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dc.contributor.authorOliveira, Katia Mara de
dc.contributor.authorPeterson, Erica J.
dc.contributor.authorCarroccia, Murilo César
dc.contributor.authorCominetti, Márcia Regina
dc.contributor.authorDeflon, Victor Marcelo
dc.contributor.authorFarrell, Nicholas P.
dc.contributor.authorBatista, Alzir Azevedo
dc.contributor.authorCorrea, Rodrigo de Souza
dc.date.accessioned2022-01-10T16:47:40Z
dc.date.available2022-01-10T16:47:40Z
dc.date.issued2020pt_BR
dc.description.abstractSix new ruthenium(II) complexes with lapachol (Lap) and lawsone (Law) with the general formula [Ru(L)(P– P)(bipy)]PF6, where L = Lap or Law, P–P = 1,2’-bis(diphenylphosphino)ethane (dppe), 1,4’-bis(diphenyl phosphino)butane (dppb), 1,1’-bis(diphenylphosphino)ferrocene (dppf) and bipy = 2,2’-bipyridine, were synthesized, fully characterized by elemental analysis, molar conductivity, NMR, cyclic voltammetry, UV vis, IR spectroscopies and three of them by X-ray crystallography. All six complexes were active against breast (MCF-7 and MDA-MB-231) and prostate (DU-145) cancer cell lines with lower IC50 values than cis platin. Complex [Ru(Lap)(dppe)(bipy)]PF6 (1a) showed significant selectivity for MDA-MB-231, a model of triple-negative breast cancer (TNBC), as compared to the “normal-like” human breast epithelial cell line, MCF-10A. Complex (1a) inhibited TNBC colony formation and induced loss of cellular adhesion. Furthermore, the complex (1a) induced mitochondrial dysfunction and generation of ROS, as is involved in the apoptotic cell death pathway. Preferential cellular uptake of complex (1a) was observed in MDA-MB-231 cells compared to MCF-10A cells, consistent with the observed selectivity for tumorigenic vs. non-tumorigenic cells. Taken together, these results indicate that ruthenium complexes containing lapachol and lawsone as ligands are promising candidates as chemotherapeutic agents.pt_BR
dc.identifier.citationOLIVEIRA, K. M. de et al. Ru(II)-naphthoquinone complexes with high selectivity for triple negative breast cancer. Dalton Transactions, v. 49, p. 16193-16203, 2020. Disponível em: <https://pubs.rsc.org/en/content/articlelanding/2020/dt/d0dt01091j>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.doihttps://doi.org/10.1039/D0DT01091Jpt_BR
dc.identifier.issn1477-9234
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/14300
dc.identifier.uri2https://pubs.rsc.org/en/content/articlelanding/2020/dt/d0dt01091jpt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.titleRu(II)-naphthoquinone complexes with high selectivity for triple negative breast cancer.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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