Lung function of patients hospitalized with COVID-19 at 45 days after hospital discharge : first report of a prospective multicenter study in Brazil.
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Date
2021
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Abstract
Objective: Because SARS-CoV-2 infection can severely affect the lungs and persistent
functional changes can occur after severe disease, we aimed to determine lung function
parameters of COVID-19 patients at 45 days after hospital discharge and compare
changes according to the severity of the disease. Methods: This was a prospective
descriptive analytical multicenter study. The participants were allocated into three
groups: ward admission (WA) group; ICU admission not on mechanical ventilation (ICU/
MV−) group; and ICU admission on MV (ICU/MV+) group. Lung volumes, DLco, MIP,
MEP, and six-minute walk distance (6MWD) were measured 45 days after discharge.
Results: The sample comprised 242 patients (mean age = 59.4 ± 14.8 years; 52.1% of
males), and 232 (96%) had altered lung function. In the total cohort, restrictive disorder
was observed in 96%, as well as reductions in DLco (in 21.2% of the patients), FEV1
/FVC
(in 39.7%), and PEmax (in 95.8%), with no differences between the groups. Comparing
the groups, the ICU/MV+ group had reduced DLco in 50% of the patients (p < 0.001)
and a lower mean 6MWD % of the predicted value (p = 0.013). Oxygen desaturation
in the six-minute walk test was observed in 32.3% of the cohort and was less frequent
in the IE group. Conclusions: This is the first South American study involving severe
COVID-19 survivors whose lung function was assessed 45 days after hospital discharge.
Changes were frequent, especially in those on MV, which highlights the importance of
lung function evaluation after severe COVID-19.
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Keywords
Respiratory function tests, Pulmonary diffusing capacity, Virus disease, SARS-CoV-2
Citation
MANCUZO, E. V. et al. Lung function of patients hospitalized with COVID-19 at 45 days after hospital discharge: first report of a prospective multicenter study in Brazil. Jornal Brasileiro de Pneumologia, v. 47, n. 6, artigo e20210162, 2021. Disponível em: <https://www.scielo.br/j/jbpneu/a/zqdZPHpqHFJYKKB3ntnHwLM/abstract/?lang=en>. Acesso em: 11 out. 2022.