Trypanosoma cruzi : desferrioxamine decreases mortality and parasitemia in infected mice through a trypanostatic effect.

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dc.contributor.authorArantes, Jerusa Marilda
dc.contributor.authorFrancisco, Amanda Fortes
dc.contributor.authorVieira, Paula Melo de Abreu
dc.contributor.authorSilva, Maísa
dc.contributor.authorAraújo, Márcio Sobreira Silva
dc.contributor.authorCarvalho, Andréa Teixeira de
dc.contributor.authorPedrosa, Maria Lúcia
dc.contributor.authorCarneiro, Cláudia Martins
dc.contributor.authorTafuri, Washington Luiz
dc.contributor.authorMartins Filho, Olindo Assis
dc.contributor.authorSantos, Silvana Maria Elói
dc.date.accessioned2012-09-12T15:02:31Z
dc.date.available2012-09-12T15:02:31Z
dc.date.issued2011
dc.description.abstractDesferrioxamine (DFO) is a potent iron chelator that is also known to modulate inflammation and act as an efficient antioxidant under normal conditions and under oxidative stress. Many in vitro and in vivo studies have shown the efficacy of DFO in the treatment of viral, bacterial and protozoan infections. DFO is known to reduce the intensity of Trypanosoma cruzi infections in mice even during a course of therapy that is not effective in maintaining anaemia or low iron levels. To further clarify these findings, we investigated the action of DFO on mouse T. cruzi infection outcomes and the direct impact of DFO on parasites. Infected animals treated with DFO (5 mg/animal/day) for 35 days, beginning 14 days prior to infection, presented lower parasitemia and lower cumulative mortality rate. No significant effect was observed on iron metabolism markers, erythrograms, leukograms or lymphocyte subsets. In the rapid method for testing in vivo T. cruzi susceptibility, DFO also induced lower parasitemia. In regard to its direct impact on parasites, DFO slightly inhibited the growth of amastigotes and trypomastigotes in fibroblast culture. Trypan blue staining showed no effects of DFO on parasite viability, and only minor apoptosis in trypomastigotes was observed. Nevertheless, a clear decrease in parasite mobility was detected. In conclusion, the beneficial actions of DFO on mice T. cruzi infection seem to be independent of host iron metabolism and free of significant haematological side effects. Through direct action on the parasite, DFO has more effective trypanostatic than trypanocidal properties.pt_BR
dc.identifier.citationARANTES, J. M. et al. Trypanosoma cruzi : desferrioxamine decreases mortality and parasitemia in infected mice through a trypanostatic effect. Experimental Parasitology, v. 128, n. 4, p. 401-408, ago. 2011. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0014489411001603>. Acesso em: 12 set. 2012.pt_BR
dc.identifier.issn00144894
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/1383
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3280851340833.
dc.subjectTrypanosoma cruzipt_BR
dc.subjectDesferrioxaminept_BR
dc.subjectEtiological treatmentpt_BR
dc.subjectExperimental infectionpt_BR
dc.subjectTrypanostatic effectpt_BR
dc.titleTrypanosoma cruzi : desferrioxamine decreases mortality and parasitemia in infected mice through a trypanostatic effect.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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