Benznidazole, itraconazole, and their combination for the treatment of chronic experimental Chagas disease in dogs.

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dc.contributor.authorCunha, Eleonora Lima Alves
dc.contributor.authorTorchelsen, Fernanda Karoline Vieira da Silva
dc.contributor.authorFonseca, Kátia da Silva
dc.contributor.authorSousa, Lucas Resende Dutra
dc.contributor.authorVieira, Paula Melo de Abreu
dc.contributor.authorCarneiro, Cláudia Martins
dc.contributor.authorPinto, Kelerson Mauro de Castro
dc.contributor.authorTorres, Rosália Morais
dc.contributor.authorLana, Marta de
dc.date.accessioned2022-11-01T21:30:29Z
dc.date.available2022-11-01T21:30:29Z
dc.date.issued2022pt_BR
dc.description.abstractTreatment for Chagas disease has limited efficacy in the chronic phase. We evaluated benznidazole (BZ) and itraconazole (ITZ) individually and in association in dogs 16 months after infection with a BZ-resistant Trypa- nosoma cruzi strain. Four study groups (20 animals) were evaluated and treated for 60 days with BZ, ITZ, or BZ + ITZ, and maintained in parallel to control group infected and not treated (INT). All dogs were evaluated in the first, sixth, 12th, 18th and 24th months of study. Polymerase chain reaction (PCR) was negative in 2 of 3 animals in the BZ + ITZ group, 2 of 5 in the BZ group, and 4 of 5 in the ITZ group. Hemoculture performed in the 24th month was negative in all groups. Enzyme-linked immunoassay remained reactive in all treated animals. Echocardiography differentiated treated animals from control animals. Quantitative PCR analysis of cardiac tissue was negative in the BZ + ITZ and BZ groups, positive in 2 of 5 dogs in the ITZ group and in 2 of 3 dogs in the control group, but negative in colon tissue in all groups. Inflammation was significantly reduced in the right atrium and left ventricle of dogs treated with BZ + ITZ and BZ compared with those receiving ITZ alone. Fibrosis was absent in most dogs treated with BZ + ITZ, mild in those treated with BZ or ITZ alone, and intense in the control group. Parasitological and histopathological evaluations showed that BZ + ITZ treatment improved or stabilized the clinical condition of the dogs.pt_BR
dc.identifier.citationCUNHA, E. L. A. et al. Benznidazole, itraconazole, and their combination for the treatment of chronic experimental Chagas disease in dogs. Experimental Parasitology, v. 238, 2022. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0014489422000601?via%3Dihub>. Acesso em: 11 out. 2022.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.exppara.2022.108266pt_BR
dc.identifier.issn0014-4894
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/15727
dc.identifier.uri2https://www.sciencedirect.com/science/article/pii/S0014489422000601?via%3Dihubpt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectChemotherapypt_BR
dc.subjectDrug combinationspt_BR
dc.subjectDog modelpt_BR
dc.titleBenznidazole, itraconazole, and their combination for the treatment of chronic experimental Chagas disease in dogs.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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