Antiparasitic activity and ultrastructural alterations provoked by organoruthenium complexes against Leishmania amazonensis.

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dc.contributor.authorVegas, Legna Andreina Colina
dc.contributor.authorGodinho, Joseane Lima Prado
dc.contributor.authorCoutinho, Thallita
dc.contributor.authorCorrea, Rodrigo de Souza
dc.contributor.authorSouza, Wanderley de
dc.contributor.authorRodrigues, Juliany Cola Fernandes
dc.contributor.authorBatista, Alzir Azevedo
dc.contributor.authorNavarro Acosta, Maribel Coromoto
dc.date.accessioned2019-05-08T16:08:18Z
dc.date.available2019-05-08T16:08:18Z
dc.date.issued2019
dc.description.abstractFour new organoruthenium complexes with formula [RuCl(η6-p-cymene)(μ-FCZ)]2[Cl]2 (1), [RuCl(FCZ)(η6-p-cymene)(PPh3)]PF6 (2), [RuCl(CTZ)(η6-p-cymene)(PPh3)]PF6 (3) and [RuCl(KTZ)(η6-p-cymene)(PPh3)]PF6 (4) (where FCZ: 2-(2,4-difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)-2-propanol, CTZ: 1-[(2-chlorophenyl)-diphenylmethyl-1H-imidazole] and KTZ: cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine) were synthesized, characterized and evaluated as potential inhibitors for Leishmania amazonensis growth by widely reported methods. Complexes 3 and 4 displayed effective IC50 activities against Leishmania amazonensis promastigotes and intracellular amastigotes in the range of nanomolar concentration. Scanning and transmission electron microscopy analysis of Leishmania amazonensis promastigotes after treatment with 300 or 500 nM of complexes 3 and 4 for 48 h showed morphological alterations in the cell surface, a shortening of the flagellum, loss of mitochondrial matrix, disorganization of the kDNA and abnormal chromatin condensation. Thus, our strategy of incorporating a ruthenium atom into the structure of clinical drugs to improve their efficacy continues to demonstrate suitability for metallodrug discovery purposes.pt_BR
dc.identifier.citationVEGAS, L. A. C. et al. Antiparasitic activity and ultrastructural alterations provoked by organoruthenium complexes against Leishmania amazonensis. New Journal of Chemistry, v. 43, p. 1431-1439, 2019. Disponível em: <https://pubs.rsc.org/en/content/articlelanding/2019/nj/c8nj04657c#!divAbstract>. Acesso em: 7 mar. 2019.pt_BR
dc.identifier.doihttp://doi.org/10.1039/c8nj04657cpt_BR
dc.identifier.issn1369-9261
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/11230
dc.identifier.uri2https://pubs.rsc.org/en/content/articlelanding/2019/NJ/C8NJ04657C#!divAbstractpt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.titleAntiparasitic activity and ultrastructural alterations provoked by organoruthenium complexes against Leishmania amazonensis.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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