Apolipoprotein e polymorphism in Brazilian dyslipidemic individuals : Ouro Preto study.

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dc.contributor.authorLana, Angelo Mendes
dc.contributor.authorPena, Geórgia das Graças
dc.contributor.authorFreitas, Silvia Nascimento de
dc.contributor.authorLima, Angélica Alves
dc.contributor.authorNicolato, Roney Luiz de Carvalho
dc.contributor.authorNascimento Neto, Raimundo Marques do
dc.contributor.authorCoelho, George Luiz Lins Machado
dc.contributor.authorFreitas, Renata Nascimento de
dc.date.accessioned2012-07-12T13:50:53Z
dc.date.available2012-07-12T13:50:53Z
dc.date.issued2007
dc.description.abstractThe influence of apolipoprotein E alleles and genotypes on plasma lipid levels was determined in 185 individuals of mixed ethnicity living in Ouro Preto, Brazil. DNA was obtained from blood samples and the genotypes were determined by an RFLP-PCR procedure. The *3 allele was the most frequent (72%), followed by *4 (20%) and *2 (8%); *4 frequency was higher and *2 frequency was lower in the dyslipidemic group than in the normal control group. The *2 carriers presented lower LDL and total cholesterol levels compared to the *3 and *4 carriers. All six expected genotypes were observed in the individuals genotyped: E2/2 (2.1%), E4/4 (2.7%), E2/4 (3.7%), E2/3 (8.0%), E3/3 (53.3%), E3/4 (29.9%); no difference in genotype frequencies was found between the normal and dyslipidemic groups. Compared with *2, the presence of *3 increases more than two times the risk for dyslipidemia (OR = 2.31; P = 0.025; 95% CI = 1.06-5.06) and the presence of *4 increases it three times (OR = 3.31; P = 0.006; 95% CI = 1.36-8.04). The only significant effect of genotype was an increased risk for dyslipidemia in the *4 genotype carriers (E3/4 + E4/ 4) compared with the *2 genotype carriers (E2/2 + E2/3) with OR = 3.69 (95% CI = 1.25-10.88). The present study indicates that in the Ouro Preto admixed population the presence of APOE *2 can confer a protective effect, whereas the presence of APOE *4 implies an enhanced risk for dyslipidemia.pt_BR
dc.identifier.citationLANA, A. M. et al. Apolipoprotein e polymorphism in Brazilian dyslipidemic individuals : Ouro Preto study. Brazilian Journal of Medical and Biological Research, v. 40, n. 1, p. 49-56, jan. 2007. Disponível em: <http://www.scielo.br/pdf/bjmbr/v40n1/6491.pdf>. Acesso em: 12 jul. 2012.pt_BR
dc.identifier.issn1414431X
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/1092
dc.language.isoen_USpt_BR
dc.rights.licenseNo permission is required from the authors or the publishers to download, reuse, reprint, modify, distribute, and/or copy articles published in the BJMBR, as long as the original authors and source are cited. Fonte: Brazilian Journal of Medical and Biological Research <http://www.bjournal.com.br/index.php?option=com_content&view=article&id=185&Itemid=139>. Acesso em: 21 jan. 2014.
dc.subjectBrazilian populationpt_BR
dc.subjectAtherosclerosispt_BR
dc.subjectApolipoprotein E polymorphismpt_BR
dc.subjectLipidspt_BR
dc.subjectDyslipidemiapt_BR
dc.titleApolipoprotein e polymorphism in Brazilian dyslipidemic individuals : Ouro Preto study.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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