Swim training does not protect mice from skeletal muscle oxidative damage following a maximum exercise test.
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Date
2011
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Abstract
We investigated whether swim training protects
skeletal muscle from oxidative damage in response to a
maximum progressive exercise. First, we investigated the
effect of swim training on the activities of the antioxidant
enzymes, superoxide dismutase (SOD), catalase (CAT) and
glutathione peroxidase (GPx), in the gastrocnemius muscle of
C57Bl/6 mice, 48 h after the last training session. Mice swam
for 90 min, twice a day, for 5 weeks at 31C (±1C). The
activities of SOD and CAT were increased in trained mice
(P\0.05) compared to untrained group. However, no effect
of training was observed in the activity of GPx. In a second
experiment, trained and untrained mice were submitted to a
maximum progressive swim test. Compared to control mice
(untrained, not acutely exercised), malondialdehyde (MDA)
levels were increased in the skeletal muscle of both trained
and untrained mice after maximum swim. The activity of
GPx was increased in the skeletal muscle of both trained and
untrained mice, while SOD activity was increased only in
trained mice after maximum swimming. CAT activity was
increased only in the untrained compared to the control
group. Although the trained mice showed increased activity
of citrate synthase in skeletal muscle, swim performance was
not different compared to untrained mice. Our results show
an imbalance in the activities of SOD, CAT and GPx in
response to swim training, which could account for the oxidative
damage observed in the skeletal muscle of trained
mice in response to maximum swim, resulting in the absence
of improved exercise performance.
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Keywords
Swim, Oxidative stress, Superoxide dismutase, Catalase
Citation
BARRETO, T. O. et al. Swim training does not protect mice from skeletal muscle oxidative damage following a maximum exercise test. European Journal of Applied Physiology, v. 112, p. 2523–2530, 2011. Disponível em:<https://link.springer.com/article/10.1007%2Fs00421-011-2211-x> . Acesso em: 16 jun. 2017.