Ru(II)-based complexes with N-(acyl)-N′,N′-(disubstituted)thiourea ligands : synthesis, characterization, BSA- and DNA-binding studies of new cytotoxic agents against lung and prostate tumour cells.

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dc.contributor.authorCorrea, Rodrigo de Souza
dc.contributor.authorOliveira, Katia Mara de
dc.contributor.authorDelolo, Fábio Godoy
dc.contributor.authorAlvarez Hernández, Anislay
dc.contributor.authorMocelo, Raúl
dc.contributor.authorPlutin, Ana M.
dc.contributor.authorCominetti, Márcia Regina
dc.contributor.authorCastellano, Eduardo Ernesto
dc.contributor.authorBatista, Alzir Azevedo
dc.date.accessioned2016-10-05T14:38:08Z
dc.date.available2016-10-05T14:38:08Z
dc.date.issued2015
dc.description.abstractFour ruthenium(II)-based complexeswith N-(acyl)-N′,N′-(disubstituted)thiourea derivatives (Th)were obtained. The compounds, with the general formula trans-[Ru(PPh3)2(Th)(bipy)]PF6, interact with bovine serum albumin (BSA) and DNA. BSA-binding constants, which were in the range of 3.3–6.5 × 104 M−1, and the thermodynamic parameters (ΔG, ΔH and ΔS), suggest spontaneous interactions with this protein by electrostatic forces due to the positive charge of the complexes. Also, binding constant by spectrophotometric DNA titration (Kb = 0.8–1.8 × 104 M−1) and viscosity studies indicate weak interactions between the complexes and DNA. Cytotoxicity assays against DU-145 (prostate cancer) and A549 (lung cancer) tumour cells revealed that the complexes are more active in tumour cells than in normal (L929) cells, and that they present high cytotoxicity (low IC50 values) compared with the reference metallodrug, cisplatin.pt_BR
dc.identifier.citationCORREA, R. de S. et al. Ru(II)-based complexes with N-(acyl)-N′,N′-(disubstituted)thiourea ligands: synthesis, characterization, BSA- and DNA-binding studies of new cytotoxic agents against lung and prostate tumour cells. Journal of Inorganic Biochemistry, v. 150, p. 63-71, 2015. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0162013415001026>. Acesso em: 26 set. 2016.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jinorgbio.2015.04.008
dc.identifier.issn0162-0134
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/7033
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseO periódico Journal of Inorganic Biochemistry concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3957611287599.pt_BR
dc.subjectAcylthiourea ligandspt_BR
dc.subjectProstate cancerpt_BR
dc.subjectLung cancerpt_BR
dc.titleRu(II)-based complexes with N-(acyl)-N′,N′-(disubstituted)thiourea ligands : synthesis, characterization, BSA- and DNA-binding studies of new cytotoxic agents against lung and prostate tumour cells.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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