Therapeutic responses to different anti-Trypanosoma cruzi drugs in experimental infection by benznidazole-resistant parasite stock.
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Date
2014
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Abstract
upon mice infection with a benznidazole-resistant Trypanosoma cruzi strain in the pathological outcomes. Trypanosoma
cruzi-infected mice were treated with different drugs and parasite clearance time was detected by blood and tissue qPCR, to
determine the dynamic relationship between the efficacy of the treatments and the intensity of heart lesion/serum
inflammatory mediators. Our results indicate that anti-T. cruzi treatments were able to reduce parasite replication and
consequently induce immunomodulatory effects, where the degree of the immunopathology prevention was related to the
time of parasite clearance induced by different treatments. Nevertheless, in benznidazole and posaconazole treatments,
parasite rebounding was detected with parasitism reaching levels similar to infected and non-treated mice; the time for
parasitic rebound being earlier among benznidazole-treated mice. In parallel, an increase of cardiac lesions and plasma
chemokine levels was also detected and was more accentuated in benznidazole-treated animals. Interestingly, in the presence
of parasitological cure (fexinidazole treatment), basal levels of these inflammatory mediators were evidenced as well as an
absence of cardiac inflammation or fibrosis. Overall, our data indicate that all treatments have positive effects on the clinical
evolution of T. cruzi infection, with success in preventing cardiac alterations being drug-dependent.
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Keywords
Chemotherapy, Inflammation, Posaconazole, Fexinidazole
Citation
CALDAS, S. et al. Therapeutic responses to different anti-Trypanosoma cruzi drugs in experimental infection by benznidazole-resistant parasite stock. Parasitology, v. 141, p. 1628-1637, 2014. Disponível em: <https://goo.gl/oNhl1T>. Acesso em: 19 fev. 2017.