Low doses of Simvastatin therapy ameliorate cardiac inflammatory remodeling in Trypanosoma cruzi-Infected dogs.

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dc.contributor.authorMelo, Lilian
dc.contributor.authorCaldas, Ivo Santana
dc.contributor.authorAzevedo, Maíra Araújo
dc.contributor.authorGonçalves, Karolina Ribeiro
dc.contributor.authorNascimento, Alvaro Fernando da Silva do
dc.contributor.authorFigueiredo, Vivian Paulino
dc.contributor.authorDiniz, Lívia de Figueiredo
dc.contributor.authorLima, Wanderson Geraldo de
dc.contributor.authorTorres, Rosália Morais
dc.contributor.authorBahia, Maria Terezinha
dc.contributor.authorSilva, André Talvani Pedrosa da
dc.date.accessioned2017-06-02T16:45:24Z
dc.date.available2017-06-02T16:45:24Z
dc.date.issued2011
dc.description.abstractChagas cardiomyopathy remodeling is based on the presence of Trypanosoma cruzi in heart tissue and on the complex inflammatory response leading to a myocardium fibrosis and alterations in conductive and functional heart parameters. This study aims to evaluate Simvastatin on the inflammatory response and heart functionality using dogs infected with Y strain of T. cruzi . Animals were treated daily with Simvastatin (20 mg) for 6 months and submitted to clinical and immunopathological evaluations. Simvastatin reduced heart expression and serum levels of interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) but not interleukin-10 (IL-10), possibly favoring blood parasitism but reducing inflammation and fibrosis in the left ventricle and right atrium. Simvastatin also ameliorated ejection fraction, diastolic diameter, and mass index of the left ventricle 6 months after infection. This study suggests that more investigation should be performed on the use of statins as a prophylactic therapy against cardiac remodeling because of their effects on modifying immune response and benefiting functional parameters in dogs with T. cruzi -induced ventricular dysfunctions.pt_BR
dc.identifier.citationMELO, L. et al. Low doses of Simvastatin therapy ameliorate cardiac inflammatory remodeling in Trypanosoma cruzi-Infected dogs. The American Journal of Tropical Medicine and Hygiene, v. 84, p. 325-331, 2011. Disponível em: <http://www.ajtmh.org/content/84/2/325>. Acesso em: 19 fev. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.4269/ajtmh.2011.10-0451
dc.identifier.issn1476-1645
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/7858
dc.identifier.uri2http://www.ajtmh.org/content/84/2/325pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.titleLow doses of Simvastatin therapy ameliorate cardiac inflammatory remodeling in Trypanosoma cruzi-Infected dogs.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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