BDKRB2 +9/−9 polymorphism Is associated with higher risk for diabetes mellitus in the Brazilian general population.

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dc.contributor.authorAlvim, Rafael de Oliveira
dc.contributor.authorSantos, Paulo Caleb Júnior de Lima
dc.contributor.authorNascimento Neto, Raimundo Marques do
dc.contributor.authorCoelho, George Luiz Lins Machado
dc.contributor.authorMill, José Geraldo
dc.contributor.authorKrieger, José Eduardo
dc.contributor.authorPereira, Alexandre da Costa
dc.date.accessioned2014-11-12T19:47:48Z
dc.date.available2014-11-12T19:47:48Z
dc.date.issued2012
dc.description.abstractSome mechanisms have been proposed to explain the role of bradykinin on glucose homeostasis and some studies reported that the BDKRB2 +9/−9 polymorphism was associated to the transcriptional activity of the receptor. In this scenario, the main aim of this study was to evaluate the association of the BDKRB2 +9/−9 polymorphism with diabetes mellitus risk in the Brazilian general population. This study included 1,032 subjects of the general urban population. Anthropometrical, blood pressure, biochemical, and genotype analyses for the BDKRB2 +9/−9 bp insertion/deletion polymorphism were performed. Individuals carrying +9/+9 or +9/−9 genotypes had higher glucose values (84.5mg/dL versus 80.6mg/dL, resp.) and higher frequency of diabetes mellitus (7.6% versus 3.6%, resp.) compared to individuals carrying −9/−9, adjusting for age and gender. In addition, higher diabetes mellitus risk was associated to presence of the +9/+9 or +9/−9 genotypes (OR= 1.91; 95% CI = 1.09–4.19; P = 0.03). Our data suggest that the BDKRB2 +9/-9 polymorphismmay act as a geneticmodulator of glucose homeostasis. It was previously associated to insulin sensitivity, glucose uptake, and insulin secretion, and, in this study, data suggest that the polymorphism may increase susceptibility to chronic metabolic conditions such as diabetes in the Brazilian population.pt_BR
dc.identifier.citationALVIM. R. O. et al. BDKRB2 +9/−9 polymorphism Is associated with higher risk for diabetes mellitus in the Brazilian general population. Experimental Diabetes Research, v. 2012, p. 1-4, 2012. Disponível em: <http://www.hindawi.com/journals/jdr/2012/480251/>. Acesso em: 01 set. 2014.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1155/2012/480251
dc.identifier.issn2163-1646
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/3831
dc.language.isoen_USpt_BR
dc.rights.licenseThis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: Experimental Diabetes Research <http://www.hindawi.com/journals/jdr/2012/480251/>. Acesso em: 01 set. 2014.pt_BR
dc.titleBDKRB2 +9/−9 polymorphism Is associated with higher risk for diabetes mellitus in the Brazilian general population.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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