Carvedilol : decomposition kinetics and compatibility with pharmaceutical excipients.

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dc.contributor.authorSilva, André Talvani Pedrosa da
dc.contributor.authorBahia, Maria Terezinha
dc.contributor.authorBarreto, Lívia Cristina Lira de Sá
dc.contributor.authorLima, Eliana Martins
dc.contributor.authorCunha Filho, Marcílio Sérgio Soares da
dc.date.accessioned2017-05-31T17:10:21Z
dc.date.available2017-05-31T17:10:21Z
dc.date.issued2014
dc.description.abstractCarvedilol (CARVE) is an important cardiovascular drug with limited bioavailability. To improve its therapeutic performance, the investigation of new dosage forms is of great interest due its relevance in clinical applications. Therefore, the aim of this work was to evaluate the stability of CARVE and its drug–excipient compatibility to support its pharmaceutical development. Kinetic analysis under isothermal conditions using thermogravimetry was performed to determine the activation energy of CARVE through an Arrhenius plot. Differential scanning calorimetry, Fourier transform infrared spectroscopy, and optical microscopy were used to test binary mixtures of CARVE and selected excipients. The activation energy of CARVE was 81.2 kJ mol-1, and from the compatibility studies, all the excipients showed strong thermal interactions, presenting changes in the melting profile of the drug. In addition, analytical assays revealed no physical or chemical changes; because of this, all eight excipients studied are considered compatible and are recommended in formulations containing CARVE. All the evidence together attests to the low chemical reactivity of CARVE and provides useful information for the development of new pharmaceutical formulations containing CARVE.pt_BR
dc.identifier.citationTALVANI, A. et al. Carvedilol: decomposition kinetics and compatibility with pharmaceutical excipients. Journal of Thermal Analysis and Calorimetry, v. 115, p. 2501-2506, 2014. Disponível em: <http://link.springer.com/article/10.1007/s10973-013-3491-7>. Acesso em: 19 fev. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1007/s10973-013-3491-7
dc.identifier.issn1588-2926
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/7840
dc.identifier.uri2http://link.springer.com/article/10.1007/s10973-013-3491-7pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectActivation energypt_BR
dc.subjectCompatibilitypt_BR
dc.subjectDifferential scanning calorimetrypt_BR
dc.subjectIsothermal thermogravimetrypt_BR
dc.titleCarvedilol : decomposition kinetics and compatibility with pharmaceutical excipients.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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