Severe food restriction activates the central renin angiotensin system.

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dc.contributor.authorSouza, Aline Maria Arlindo de
dc.contributor.authorLinares, Andrea
dc.contributor.authorSpeth, Robert
dc.contributor.authorCampos, Glenda Siqueira Viggiano
dc.contributor.authorJi, Hong
dc.contributor.authorChianca Júnior, Deoclécio Alves
dc.contributor.authorSandberg, Kathryn
dc.contributor.authorMenezes, Rodrigo Cunha Alvim de
dc.date.accessioned2021-11-22T11:41:18Z
dc.date.available2021-11-22T11:41:18Z
dc.date.issued2020pt_BR
dc.description.abstractWe previously showed that 2 weeks of a severe food restricted (sFR) diet (40% of the caloric intake of the control (CT) diet) up-regulated the circulating renin angiotensin (Ang) system (RAS) in female Fischer rats, most likely as a result of the fall in plasma volume. In this study, we investigated the role of the central RAS in the mean arterial pressure (MAP) and heart rate (HR) dysregulation associated with sFR. Although sFR reduced basal mean MAP and HR, the magnitude of the pressor response to intracerebroventricular (icv) microinjection of Ang-[1-8] was not affected; however, HR was 57 ± 13 bpm lower 26 min after Ang-[1-8] microinjection in the sFR rats and a similar response was observed after losartan was microinjected. The major catabolic pathway of Ang-[1-8] in the hypothalamus was via Ang-[1-7]; however, no differences were detected in the rate of Ang-[1-8] synthesis or degradation between CT and sFR animals. While sFR had no effect on the AT1R binding in the subfornical organ (SFO), the organum vasculosum laminae terminalis (OVLT) and median preoptic nucleus (MnPO) of the paraventricular anteroventral third ventricle, ligand binding increased 1.4-fold in the paraventricular nucleus (PVN) of the hypothalamus. These findings suggest that sFR stimulates the central RAS by increasing AT1R expression in the PVN as a compensatory response to the reduction in basal MAP and HR. These findings have implications for people experiencing a period of sFR since an activated central RAS could increase their risk of disorders involving over activation of the RAS including renal and cardiovascular diseases.pt_BR
dc.identifier.citationSOUZA, A. M. A. de et al. Severe food restriction activates the central renin angiotensin system. Physiological Reports, v. 8, p. 1-12, 2020. Disponível em: <https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.14338>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.doihttps://doi.org/10.14814/phy2.14338pt_BR
dc.identifier.issn2051-817X
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/13978
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Source: The article PDF.pt_BR
dc.subjectAngiotensin converting enzyme (ACE)pt_BR
dc.subjectAngiotensin converting enzyme 2 (ACE2)pt_BR
dc.subjectCaloric reductionpt_BR
dc.subjectInadequate food intakept_BR
dc.subjectRAS-Fingerprintpt_BR
dc.titleSevere food restriction activates the central renin angiotensin system.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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