Polyphenols for improvement of inflammation and symptoms in rheumatic diseases : systematic review.
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Date
2021
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Abstract
BACKGROUND: Rheumatic diseases (RDs) are a group of pathological conditions characterized by inflam-
mation and functional disability. There is evidence suggesting that regular consumption of polyphenols
has therapeutic effects capable of relieving RD symptoms.
OBJECTIVE: To synthesize data from randomized controlled trials on administration of polyphenols and
their effects on RD activity.
DESIGN AND SETTING: Systematic review conducted at Universidade Federal de Ouro Preto, Minas
Gerais, Brazil.
METHODS: A systematic search was conducted in the databases PubMed (Medline), LILACS (BVS), IBECS
(BVS), CUMED (BVS), BINACIS (BVS), EMBASE, Web of Science and Cochrane Library and in the grey litera-
ture. The present study followed a PRISMA-P checklist.
RESULTS: In total, 646 articles were considered potentially eligible, of which 33 were then subjected to
complete reading. Out of these, 17 randomized controlled trials articles were selected to form the final
sample. Among these 17 articles, 64.71% assessed osteoarthritis (n = 11), 23.53% rheumatoid arthritis
(n = 4), 5.88% rheumatoid arthritis and fibromyalgia (n = 1) and 5.88% osteoarthritis and rheumatoid
(n = 1). Intake of polyphenol showed positive effects in most of the studies assessed (94.12%): it improved
pain (64.70%) and inflammation (58.82%).
CONCLUSION: Polyphenols are potential allies for treating RD activity. However, the range of polyphenol
sources administered was a limitation of this review, as also was the lack of information about the meth-
odological characteristics of the studies evaluated. Thus, further primary studies are needed in order to
evaluate the effects of polyphenol consumption for reducing RD activity.
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Keywords
Antioxidants, Rheumatic diseases, Polyphenols, Rheumatoid arthritis, Osteoarthritis
Citation
COLETRO, H. N. et al. Polyphenols for improvement of inflammation and symptoms in rheumatic diseases: systematic review. São Paulo Medical Journal, v. 139, n. 6, p. 615-623, 2021. Disponível em: <https://www.scielo.br/j/spmj/a/9gsypp88wfZfKZrgRKqLs7D/?lang=en>. Acesso em: 11 out. 2022.