Alpha-actinin-3 R577X polymorphism influences muscle damage and hormonal responses after a soccer game.
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Date
2018
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Abstract
The purpose of this
study was to evaluate indicators of muscle damage and hormonal
responses after soccer matches and its relation to alpha-actinin-3
(ACTN3) gene expression (XX vs. RR/RX), considering that the R
allele produces alpha-actinin-3 and provides greater muscle
strength and power. Thirty players (10 XX and 20 RR/RX) younger than 16 years were evaluated in this study. Blood samples
were collected immediately before, after, 2, and 4 hours after the
games to assess muscle damage (creatine kinase [CK] and
alpha-actin) and hormonal responses (interleukin-6 [IL-6], cortisol,
and testosterone). Postgame CK was higher as compared to the
pregame values in both groups and it was also higher in the RR/
RX (p , 0.05) than in the XX. The concentrations of alpha-actin
and IL-6 were similar for both groups and did not change over
time. Testosterone was increased after the game only in the RR/
RX group (p , 0.05). Cortisol concentrations in group RR/RX
were higher immediately after the game than before the game, and
2 and 4 hours after the game the concentration decreased
(p , 0.05). The RR and RX individuals presented higher markers
of muscle microtrauma and hormonal stress, probably because
they performed more speed and power actions during the game,
which is a self-regulated activity. From the different responses
presented by RR/RX and XX genotypes, we conclude that the
genotypic profile should be taken into account when planning
training workloads and recovery of athletes
Description
Keywords
ACTN3, Physiological stress, Performance, Muscle microtrauma, Blood markers
Citation
COELHO, D. B. et al. Alpha-actinin-3 R577X polymorphism influences muscle damage and hormonal responses after a soccer game. Journal of Strength and Conditioning Research, v. Published Ahead-of-Print, p. 3-10, maio 2018. Disponível em: <https://journals.lww.com/nsca-jscr/Abstract/publishahead/Alpha_Actinin_3_R577X_Polymorphism_Influences.95358.aspx>. Acesso em: 20 fev. 2019.