Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis.

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dc.contributor.authorPinto, Flávia Carmo Horta
dc.contributor.authorCunha Júnior, Armando da Silva
dc.contributor.authorOréfice, Rodrigo Lambert
dc.contributor.authorAyres, Eliane
dc.contributor.authorAndrade, Silvia Passos de
dc.contributor.authorLima, Luiza Dias da Cunha
dc.contributor.authorMoura, Sandra Aparecida Lima de
dc.contributor.authorSilva, Gisele Rodrigues da
dc.date.accessioned2017-06-23T16:54:44Z
dc.date.available2017-06-23T16:54:44Z
dc.date.issued2012
dc.description.abstractThe purpose of this study was to develop triamcinolone acetonide-loaded polyurethane implants (TA PU implants) for the local treatment of different pathologies including arthritis, ocular and neuroinflammatory disorders. The TA PU implants were characterized by FTIR, SAXS and WAXS. The in vitro and in vivo release of TA from the PU implants was evaluated. The efficacy of TA PU implants in suppressing inflammatory-angiogenesis in a murine sponge model was demonstrated. FTIR results revealed no chemical interactions between polymer and drug. SAXS results indicated that the incorporation of the drug did not disturb the polymer morphology. WAXS showed that the crystalline nature of the TA was preserved after incorporation into the PU. The TA released from the PU implants efficiently inhibited the inflammatory-angiogenesis induced by sponge discs in an experimental animal model. Finally, TA PU implants could be used as local drug delivery systems because of their controlled delivery of TA.pt_BR
dc.identifier.citationPINTO, F. C. H. et al. Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis. Journal of Materials Science. Materials in Medicine, v. 6, p. 1431-1445, 2012. Disponível em: <https://link.springer.com/article/10.1007%2Fs10856-012-4615-5>. Acesso em: 20 mar. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1007/s10856-012-4615-5
dc.identifier.issn1573-4838
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/8060
dc.identifier.uri2https://link.springer.com/article/10.1007%2Fs10856-012-4615-5pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.titleControlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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