Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids.

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dc.contributor.authorSantos, Edjane Rocha dos
dc.contributor.authorCorrea, Rodrigo de Souza
dc.contributor.authorCunha, Lucas Vinícius Pozzi da
dc.contributor.authorGraminha, Angelica Ellen
dc.contributor.authorAraujo, Heloisa Sobreiro Selistre de
dc.contributor.authorPavan, Fernando Rogério
dc.contributor.authorBatista, Alzir Azevedo
dc.date.accessioned2018-03-14T13:08:57Z
dc.date.available2018-03-14T13:08:57Z
dc.date.issued2017
dc.description.abstractSix new complexes of Ru(II)/phenanthroline/1,4-bis(diphenylphosphino)butane containing amino acids (Glycine, L-Alanine, L-Valine, L-Tyrosine, L-Methionine or L-Tryptophan) were synthesized and characterized by IR, 31P{1H}, 13C and 1H NMR spectroscopies and cyclic voltammetry experiments. These data suggest the presence of diastereoisomers, except for the complex with glycine, amino acid that does not exhibit chiral carbon. The compounds are active against the MDA-MB-231 tumor cells and against Mycobacterium tuberculosis. The cationic ruthenium complexes with amino acids, reported here, show similar cytotoxicity against the MDA-MB-231 tumor cells. When compared with analogs complexes containing 2,20-bipyridine as ligands, instead of 1,10-phenatroline, the new complexes studied here are, in general, roughly twice more active than the 2,20-bipyridine ones and their IC50 values comparable with the cisplatin. In addition, low MICs values were obtained against Mycobacterium tuberculosis compared with the reference drugs, cycloserine and ethambutol.pt_BR
dc.identifier.citationSANTOS, E. R. dos et al. Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids. Inorganica Chimica Acta, v. 463, p. 1-6, jul. 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0020169317304681>. Acesso em: 15 set. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.ica.2017.04.012
dc.identifier.issn0020-1693
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/9628
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseO periódico Inorganica Chimica Acta concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 4211380089785.pt_BR
dc.subjectRuthenium complexespt_BR
dc.subjectCytotoxicitypt_BR
dc.subjectDiastereoisomerspt_BR
dc.subjectAmino acidpt_BR
dc.titleAntitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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