Cardiovascular responses to L-glutamate microinjection into the NTS are abrogated by reduced glutathione.

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dc.contributor.authorGranato, Álisson Silva
dc.contributor.authorGomes, Paula Magalhães
dc.contributor.authorSá, Renato Willian Martins
dc.contributor.authorBorges, Gabriel Silva Marques
dc.contributor.authorAlzamora, Andréia Carvalho
dc.contributor.authorOliveira, Lisandra Brandino de
dc.contributor.authorToney, Glenn M.
dc.contributor.authorCardoso, Leonardo Máximo
dc.date.accessioned2017-11-27T15:55:59Z
dc.date.available2017-11-27T15:55:59Z
dc.date.issued2017
dc.description.abstractRedox imbalance in regions of the CNS controlling blood pressure is increasingly recognized as a leading factor for hypertension. Nucleus tractus solitarius (NTS) of the dorsomedial medulla is the main region receiving excitatory visceral sensory inputs that modulate autonomic efferent drive to the cardiovascular system. This study sought to determine the capacity of reduced glutathione, a major bioactive antioxidant, to modulate NTS-mediated control of cardiovascular function in unanaesthetized rats. Male Fischer 344 rats were used for microinjection experiments. Cardiovascular responses to l-glutamate were first used to verify accurate placement of injections into the dorsomedial region comprising the NTS. Next, responses to GSH or vehicle were recorded followed by responses to l-glutamate again at the same site. GSH microinjection increased mean arterial pressure (MAP) compared to vehicle and abrogated responses to subsequent injection of l-glutamate. These data indicate that GSH microinjection into the NTS affects blood pressure regulation by dorsomedial neuronal circuits and blunts l-glutamate driven excitation in this region. These findings raise the possibility that increased antioxidant actions of GSH in NTS could contribute to autonomic control dysfunctions of the cardiovascular system.pt_BR
dc.identifier.citationGRANATO, A. S. et al. Cardiovascular responses to L-glutamate microinjection into the NTS are abrogated by reduced glutathione. Neuroscience Letters, v. 642, p. 142-147, 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0304394017301258?via%3Dihub>. Acesso em: 15 set. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.neulet.2017.02.019
dc.identifier.issn0304-3940
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/9180
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseO periódico Neuroscience Letters concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 4210820629012.pt_BR
dc.subjectBlood pressurept_BR
dc.subjectNucleus tractus solitariespt_BR
dc.titleCardiovascular responses to L-glutamate microinjection into the NTS are abrogated by reduced glutathione.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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