Protein deficiency alters CX3CL1 and endothelin-1 in experimental Trypanosoma cruzi-induced cardiomyopathy.

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dc.contributor.authorMartins, Régia Ferreira
dc.contributor.authorMartinelli, Patrícia Massara
dc.contributor.authorGuedes, Paulo Marcos da Matta
dc.contributor.authorPádua, Bruno da Cruz
dc.contributor.authorSantos, Fabiane Matos dos
dc.contributor.authorSilva, Marcelo Eustáquio
dc.contributor.authorBahia, Maria Terezinha
dc.contributor.authorSilva, André Talvani Pedrosa da
dc.date.accessioned2017-06-02T16:43:06Z
dc.date.available2017-06-02T16:43:06Z
dc.date.issued2013
dc.description.abstractobjective Chagas heart disease is developed as a result of the infection with Trypanosoma cruzi. Protein malnutrition contributes to secondary immunodeficiency. The aim of this study was to investigate the role of a low protein diet on the production of endothelin-1 and CX3CL1 in blood and cardiac tissue samples in an experimental model with T. cruzi infection. methods Fisher rats were submitted to low protein (6%) and normal protein (15%) diets and then infected with the Y strain of T. cruzi. At days 15 and 120, parasites and immune cells were evaluated. results The low protein diet reduced body weight and circulating serum proteins, but promoted elevation of CX3CL1 and endothelin-1 levels in infected animals, which were unable to control blood parasitemia replication. In heart tissue, the low protein diet reduced cardiac CX3CL1, endothelin-1 and leucocyte infiltration in the acute phase, in particular CD68 and CD163 macrophage phenotypes. conclusion Together, these results highlight the participation of endothelin-1 and CX3CL1 in the inflammatory process of Chagas diesease, both being mediators partially controlled by the host nutritional status.pt_BR
dc.identifier.citationMARTINS, R. F. et al. Protein deficiency alters CX3CL1 and endothelin-1 in experimental Trypanosoma cruzi-induced cardiomyopathy. TM & IH. Tropical Medicine and International Health, v. 18, p. 466-476, 2013. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1111/tmi.12071/abstract>. Acesso em: 19 fev. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1111/tmi.12071
dc.identifier.issn1365-3156
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/7856
dc.identifier.uri2http://onlinelibrary.wiley.com/doi/10.1111/tmi.12071/abstractpt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectLow protein dietpt_BR
dc.subjectInflammationpt_BR
dc.subjectChagas heart diseasept_BR
dc.titleProtein deficiency alters CX3CL1 and endothelin-1 in experimental Trypanosoma cruzi-induced cardiomyopathy.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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