Diet rich in lard promotes a metabolic environment favorable to Trypanosoma cruzi growth.

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dc.contributor.authorSouza, Débora Maria Soares de
dc.contributor.authorSilva, Maria Cláudia
dc.contributor.authorFarias, Sílvia Elvira Barros
dc.contributor.authorMenezes, Ana Paula de Jesus
dc.contributor.authorMilanezi, Cristiane Maria
dc.contributor.authorLúcio, Karine de Pádua
dc.contributor.authorPaiva, Nívia Carolina Nogueira de
dc.contributor.authorVieira, Paula Melo de Abreu
dc.contributor.authorCosta, Daniela Caldeira
dc.contributor.authorPinto, Kelerson Mauro de Castro
dc.contributor.authorCosta, Guilherme de Paula
dc.contributor.authorSilva, João Santana da
dc.contributor.authorSilva, André Talvani Pedrosa da
dc.date.accessioned2021-11-22T11:54:53Z
dc.date.available2021-11-22T11:54:53Z
dc.date.issued2021pt_BR
dc.description.abstractBackground: Trypanosoma cruzi is a protozoan parasite that causes Chagas disease and affects 6–7 million people mainly in Latin America and worldwide. Here, we investigated the effects of hyperlipidic diets, mainly composed of olive oil or lard on experimental T. cruzi infection. C57BL/6 mice were fed two different dietary types in which the main sources of fatty acids were either monounsaturated (olive oil diet) or saturated (lard diet). Methods: After 60 days on the diet, mice were infected with 50 trypomastigote forms of T. cruzi Colombian strain. We evaluated the systemic and tissue parasitism, tissue inflammation, and the redox status of mice after 30 days of infection. Results: Lipid levels in the liver of mice fed with the lard diet increased compared with that of the mice fed with olive oil or normolipidic diets. The lard diet group presented with an increased parasitic load in the heart and adipose tissues following infection as well as an increased expression of Tlr2 and Tlr9 in the heart. However, no changes were seen in the survival rates across the dietary groups. Infected mice receiving all diets presented comparable levels of recruited inflammatory cells at 30 days post-infection but, at this time, we observed lard diet inducing an overproduction of CCL2 in the cardiac tissue and its inhibition in the adipose tissue. T. cruzi infection altered liver antioxidant levels in mice, with the lard diet group demonstrating decreased catalase (CAT) activity compared with that of other dietary groups. Conclusions: Our data demonstrated that T. cruzi growth is more favorable on tissue of mice subjected to the lard diet. Our findings supported our hypothesis of a relationship between the source of dietary lipids and parasite-induced immunopathology.pt_BR
dc.identifier.citationSOUZA, D. M. S. de et al. Diet rich in lard promotes a metabolic environment favorable to Trypanosoma cruzi growth. Frontiers in Cardiovascular Medicine, v. 8, maio 2021. Disponível em: <https://www.frontiersin.org/articles/10.3389/fcvm.2021.667580/full>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.doihttps://doi.org/10.3389/fcvm.2021.667580pt_BR
dc.identifier.issn2297-055X
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/13984
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Fonte: o PDF do artigo.pt_BR
dc.subjectInflammationpt_BR
dc.subjectSaturated fatty acidspt_BR
dc.subjectMonounsaturated fatty acidspt_BR
dc.subjectAdipose tissuept_BR
dc.subjectCardiac tissuept_BR
dc.titleDiet rich in lard promotes a metabolic environment favorable to Trypanosoma cruzi growth.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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