Antitumor effect of Cymbopogon densiflorus (Linneu) essential oil in bladder cancer cells.

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dc.contributor.authorPereira, Gizele Lucia da Costa
dc.contributor.authorAlmeida, Tamires Cunha
dc.contributor.authorSeibert, Janaína Brandão
dc.contributor.authorAmparo, Tatiane Roquete
dc.contributor.authorSoares, Rodrigo Dian de Oliveira Aguiar
dc.contributor.authorRodrigues, Ivanildes Vasconcelos
dc.contributor.authorSouza, Gustavo Henrique Bianco de
dc.contributor.authorSantos, Orlando David Henrique dos
dc.contributor.authorSilva, Glenda Nicioli da
dc.date.accessioned2021-09-13T18:19:35Z
dc.date.available2021-09-13T18:19:35Z
dc.date.issued2020pt_BR
dc.description.abstractThe aim of this study was to analyse the antitumor effect of the Cymbopogon densiflorus essential oil in silico and in vitro on bladder cancer cells RT4 and T24, with different TP53 status. The oil was extracted by hydrodistillation and the gas chromatography coupled to the mass spectrometry was used for characterisation. In silico analysis was carried out by Pass online software. Cytotoxicity, cell proliferation, cell cycle progression, apoptosis and wound healing assays were performed. Five major compounds were identified. In silico analysis showed that major compounds present high potential for antitumor activities. The treatment with C. densiflorus essential oil reduced cell viability of bladder cancer cells. Only in wild-type cells, the increase of apoptosis rates and the decrease of cell migration were observed. In conclusion, the C. densiflorus essential oil presents antitumor effects on TP53 wild-type and mutated bladder cancer cells, however, the mechanism of action is TP53 status-dependent.pt_BR
dc.identifier.citationPEREIRA, G. L. da C. et al. Antitumor effect of Cymbopogon densiflorus (Linneu) essential oil in bladder cancer cells. Natural Products Reserach, abr. 2020. Disponível em: <https://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1747453?journalCode=gnpl20>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.doihttps://doi.org/10.1080/14786419.2020.1747453pt_BR
dc.identifier.issn1478-6427
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/13700
dc.identifier.uri2https://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1747453?journalCode=gnpl20pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectCytotoxicitypt_BR
dc.subjectIn silico analysespt_BR
dc.titleAntitumor effect of Cymbopogon densiflorus (Linneu) essential oil in bladder cancer cells.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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