Aerobic exercise and not a diet supplemented with jussara açaí (Euterpe edulis Martius) alters hepatic oxidative and inflammatory biomarkers in ApoE-deficient mice.

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dc.contributor.authorCastro, Cynthia Aparecida de
dc.contributor.authorNatali, Antônio José
dc.contributor.authorCardoso, Luciana Marques
dc.contributor.authorMachado, Alessandra Barbosa Ferreira
dc.contributor.authorNovello, Alexandre Azevedo
dc.contributor.authorSilva, Karina Ana da
dc.contributor.authorTafuri, Natalia Filard
dc.contributor.authorMatta, Sergio Luis Pinto da
dc.contributor.authorPedrosa, Maria Lúcia
dc.contributor.authorPeluzio, Maria do Carmo Gouveia
dc.date.accessioned2017-05-02T14:30:48Z
dc.date.available2017-05-02T14:30:48Z
dc.date.issued2014
dc.description.abstractThe pulp of jussara açaí (Euterpe edulis Martius) fruit is rich in anthocyanins that exert antioxidant and anti-inflammatory effects similar to those exerted by aerobic exercise. In the present study, we investigated the effects of jussara açaí fruit pulp consumption, either alone or in combination with aerobic exercise, on the hepatic oxidative and inflammatory status of ApoE-deficient (ApoE 2/2) mice. Male mice were divided into four groups (control (C), control plus açaí, exercise plus açaí (EXA) and exercise (EX)) and fed the AIN-93M diet or the AIN-93M diet formulated to contain 2% freeze-dried açaí pulp. Mice in the EX and EXA groups were subjected to a progressive running programme (5 d/week, 60 min/d, 16 m/min) for 12 weeks. Mice that were made to exercise exhibited reduced (40·85 %; P,0·05) hepatic superoxide dismutase activity when compared with the C mice, independent of the açaí diet. Mice in the EX group exhibited a lower (42 %; P,0·05) mRNA expression of monocyte chemotactic protein-1 in the liver compared with the C mice. Mice in the EXA and EX groups had lower percentages of hepatic lipid droplets (70% and 56 %, respectively; P,0·05) when compared with the C mice. Mice in the EX group had smaller (58 %; P,0·05) area of lesions in the aorta when compared with the C mice. Serum lipid profile was not affected (P.0·05). In conclusion, aerobic exercise training rather than açaí fruit pulp consumption or a combination of both enhances the hepatic oxidative and inflammatory status of ApoE 2/2 mice.pt_BR
dc.identifier.citationCASTRO, C. A. et al. Aerobic exercise and not a diet supplemented with jussara açaí (Euterpe edulis Martius) alters hepatic oxidative and inflammatory biomarkers in ApoE-deficient mice. British Journal of Nutrition, v. 112, p. 285-294, 2014. Disponível em: <https://goo.gl/PruUsi>. Acesso em: 23 fev. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1017/S000711451400083X
dc.identifier.issn1475-2662
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/7651
dc.identifier.uri2https://goo.gl/PruUsipt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectAtherosclerosispt_BR
dc.subjectAnthocyaninspt_BR
dc.subjectAntioxidantspt_BR
dc.subjectPhysical activitypt_BR
dc.titleAerobic exercise and not a diet supplemented with jussara açaí (Euterpe edulis Martius) alters hepatic oxidative and inflammatory biomarkers in ApoE-deficient mice.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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