Comparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazil.
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2017
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Abstract
Leishmaniasis is a highly diverse group of diseases caused by kinetoplastid of the genus Leishmania.
These parasites are taxonomically diverse, with human pathogenic species separated into two
subgenera according to their development site inside the alimentary tract of the sand fly insect
vector. The disease encompasses a variable spectrum of clinical manifestations with tegumentary or
visceral symptoms. Among the causative species in Brazil, Leishmania (Leishmania) amazonensis is an
important etiological agent of human cutaneous leishmaniasis that accounts for more than 8% of all
cases in endemic regions. L. (L.) amazonensis is generally found in the north and northeast regions of
Brazil. Here, we report the first isolation of L. (L.) amazonensis from dogs with clinical manifestations
of visceral leishmaniasis in Governador Valadares, an endemic focus in the southeastern Brazilian State
of Minas Gerais where L. (L.) infantum is also endemic. These isolates were characterized in terms of
SNPs, chromosome and gene copy number variations, confirming that they are closely related to a
previously sequenced isolate obtained in 1973 from the typical Northern range of this species. The
results presented in this article will increase our knowledge of L. (L.) amazonensis-specific adaptations
to infection, parasite survival and the transmission of this Amazonian species in a new endemic area of
Brazil.
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VALDIVIA RODRIGUEZ, H. O. et al. Comparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazil. Scientific Reports, v. 7, p. 40804, 2017. Disponível em: <https://www.nature.com/articles/srep40804>. Acesso em: 29 ago. 2017.