Trypanosoma cruzi infection induces morphological reorganization of the myocardium parenchyma and stroma, and modifies the mechanical properties of atrial and ventricular cardiomyocytes in rats.

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dc.contributor.authorNovaes, Rômulo Dias
dc.contributor.authorPenitente, Arlete Rita
dc.contributor.authorGonçalves, Reggiani Vilela
dc.contributor.authorSilva, André Talvani Pedrosa da
dc.contributor.authorPeluzio, Maria do Carmo Gouveia
dc.contributor.authorNeves, Clóvis Andrade
dc.contributor.authorNatali, Antônio José
dc.contributor.authorMaldonado, Izabel Regina dos Santos Costa
dc.date.accessioned2014-12-16T23:33:50Z
dc.date.available2014-12-16T23:33:50Z
dc.date.issued2013
dc.description.abstractBackground: This study investigates morphofunctional adaptations of the heart stroma and parenchyma in rats that are chronically infected with Trypanosoma cruzi. Methods: Four-month-old male Wistar rats were randomized into control (n=14) and infected (n=14) groups. Infected animals were inoculated with T. cruzi Y strain. After 9 weeks, the animals were euthanized, and the right atrium (RA) and left ventricle (LV) were removed for biochemical, stereological, and cardiomyocyte mechanical analyses. Results: Infected animals presented cardiomyocyte atrophy and myocardial fibrosis. For these animals, the total volume, length, surface area, and cross-sectional area of cardiomyocytes were significantly reduced, and the total interstitial and collagen volumes were significantly increased in the RA and LV compared to the controls. The total volume and length of blood vessels were significantly increased in the LV, and the total blood vessel surface area was significantly higher in the RA of infected animals. RA and LV cardiomyocytes from infected animals exhibited a significant reduction in cell shortening (43.02% and 24.98%, respectively), prolongation of the time to the peak of contraction (17.09%) and the time to half relaxation (23.68%) compared to non-infected animals. Lipid hydroperoxides, but not mineral concentrations, were significantly increased in the RA and LV from infected animals, showing an inverse correlation with cell shortening. Conclusions: T. cruzi infection induces global structural remodeling of the RA and LV in rats. This remodeling coexists with cardiomyocyte contractility dysfunction, which is possibly related to the abnormal organization of the myocardial stroma and increased cellular lipid peroxidation.pt_BR
dc.identifier.citationNOVAES, R. D. et al. Trypanosoma cruzi infection induces morphological reorganization of the myocardium parenchyma and stroma, and modifies the mechanical properties of atrial and ventricular cardiomyocytes in rats. Cardiovascular Pathology, v. 22, p. 270-279, 2013. Disponível em: <http://www.sciencedirect.com/science/article/pii/S1054880712001536>. Acesso em: 08 nov. 2014.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.carpath.2012.12.001
dc.identifier.issn1054-8807
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/4182
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Cardiovascular Pathology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3517120908487.pt_BR
dc.subjectCardiac myocytespt_BR
dc.subjectChagas diseasept_BR
dc.subjectPathologypt_BR
dc.subjectExtracellular matrixpt_BR
dc.subjectOxidative stresspt_BR
dc.titleTrypanosoma cruzi infection induces morphological reorganization of the myocardium parenchyma and stroma, and modifies the mechanical properties of atrial and ventricular cardiomyocytes in rats.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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