EPA/DHA and linseed oil have different effects on liver and adipose tissue in rats fed with a high-fat diet.

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dc.contributor.authorDias, Bruna Vidal
dc.contributor.authorGomes, Sttefany Viana
dc.contributor.authorCastro, Maria Laura da Cruz
dc.contributor.authorCarvalho, Luana Cristina Faria
dc.contributor.authorBreguez, Gustavo Silveira
dc.contributor.authorSouza, Débora Maria Soares de
dc.contributor.authorRamos, Camila de Oliveira
dc.contributor.authorSant’Ana, Marcella Ramos
dc.contributor.authorNakandakari, Susana Castelo Branco Ramos
dc.contributor.authorAraujo, Carolina Morais
dc.contributor.authorGuimaraes, Andrea Grabe
dc.contributor.authorSilva, André Talvani Pedrosa da
dc.contributor.authorCarneiro, Cláudia Martins
dc.contributor.authorCintra, Dennys Esper Corrêa
dc.contributor.authorCosta, Daniela Caldeira
dc.date.accessioned2022-12-15T21:11:15Z
dc.date.available2022-12-15T21:11:15Z
dc.date.issued2022pt_BR
dc.description.abstractThe incidence of cardiovascular diseases and metabolic disorders has increased worldwide. Clinical and exper- imental research has shown that the consumption of ω-3 FAs can be beneficial to metabolism in several ways, as they can act on metabolic pathways. Our objective was to evaluate the effect of treatment with linseed oil, a vegetable oil rich in alpha-linolenic acid, and EPA and DHA in different proportions (3:1 EPA:DHA, and 1:3 EPA: DHA), on the metabolic disorders induced by a high-fat diet (20 % lipids) in rats for 2 weeks, after 18 weeks of consumption of a high-fat diet. In 18 weeks, the high-fat diet increased blood glucose, systolic blood pressure, triglyceride concentration in the liver and adipose tissue, and impaired insulin sensibility without interfering in the weight of the animals. All treatments were effective in reducing the deposition of hepatic type III collagen, the proportion of ω-6/ω-3 in the liver and WAT (white adipose tissue), the proportion of area/number of adi- pocytes, and the gene expression of the ACC, FAS, and CPT1 enzymes. In addition, treatment with EPA and DHA reduced blood glucose, serum TNF-α concentration, amount of liver fat, degree of microsteatosis and type I collagen deposition in the liver, deposition of type I and III collagen in TA, gene expression of the transcription factor SREBP-1c, and increased hepatic binucleation. EPA in major proportion was more effective in reducing the area of adipocytes, hepatic triglyceride concentration, PPAR-α expression, and WAT fat weight. DHA in a major proportion reduced the concentration of MCP1 in WAT. LO treatment did not have any isolated effects. We concluded that EPA and DHA were more effective in treating metabolic damage than treatment with LO, leading to a more favorable metabolic profile.pt_BR
dc.identifier.citationDIAS, B. V. et al. EPA/DHA and linseed oil have different effects on liver and adipose tissue in rats fed with a high-fat diet. Prostaglandins and Other Lipid Mediators, v. 159, 2022. Disponível em: <https://www.sciencedirect.com/science/article/pii/S1098882322000120>. Acesso em: 11 out. 2022.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.prostaglandins.2022.106622pt_BR
dc.identifier.issn1098-8823
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/15915
dc.identifier.uri2https://www.sciencedirect.com/science/article/pii/S1098882322000120pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectn-3 polyunsaturated fatty acidspt_BR
dc.subjectDocosahexaenoic acidpt_BR
dc.subjectLiver metabolismpt_BR
dc.subjectWhite adipose tissuept_BR
dc.titleEPA/DHA and linseed oil have different effects on liver and adipose tissue in rats fed with a high-fat diet.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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