Successful vaccination against Leishmania chagasi infection in BALB/c mice with freeze-thawed Leishmania antigen and Corynebacterium parvum.

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dc.contributor.authorVilela, Márcia de Carvalho
dc.contributor.authorGomes, Daniel Cláudio de Oliveira
dc.contributor.authorSilva, Eduardo de Almeida Marques da
dc.contributor.authorSerafim, Tiago Donatelli
dc.contributor.authorAfonso, Luís Carlos Crocco
dc.contributor.authorRezende, Simone Aparecida
dc.date.accessioned2014-11-20T16:06:54Z
dc.date.available2014-11-20T16:06:54Z
dc.date.issued2007
dc.description.abstractThis study evaluated the potential of a Leishmania antigen vaccine in protecting BALB/c mice against Leishmania chagasi. Mice received two subcutaneous doses of L. amazonensis vaccine with Corynebacterium parvum and subsequent boost was done without adjuvant. One week later, mice were challenged with L. chagasi. We observed that this vaccine caused a significant reduction in parasite load in liver and spleen and induced a high production of IFN-_ and IL-4 by spleen cells from vaccinated mice in response to Leishmania antigen. Together, our data show that this vaccine is capable of inducing a Th1/Th2 response that is important to control parasite replication.pt_BR
dc.identifier.citationVILELA, M. de C. et al. Successful vaccination against Leishmania chagasi infection in BALB/c mice with freeze-thawed Leishmania antigen and Corynebacterium parvum. Acta Tropica, v. 104, p. 133-139, 2007. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0001706X0700215X>. Acesso em: 28 ago. 2014.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.actatropica.2007.08.007
dc.identifier.issn0001-706X
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/4007
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Acta Tropica concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3460890151852.pt_BR
dc.subjectVaccinept_BR
dc.subjectLeishmania chagasipt_BR
dc.titleSuccessful vaccination against Leishmania chagasi infection in BALB/c mice with freeze-thawed Leishmania antigen and Corynebacterium parvum.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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