Trypanosoma cruzi : impact of dual-clone infections on parasite biological properties in BALB/c mice.
| dc.contributor.author | Martins, Helen Rodrigues | |
| dc.contributor.author | Toledo, Max Jean de Ornelas | |
| dc.contributor.author | Veloso, Vanja Maria | |
| dc.contributor.author | Carneiro, Cláudia Martins | |
| dc.contributor.author | Coelho, George Luiz Lins Machado | |
| dc.contributor.author | Tafuri, Washington Luiz | |
| dc.contributor.author | Bahia, Maria Terezinha | |
| dc.contributor.author | Valadares, Helder Magno Silva | |
| dc.contributor.author | Macedo, Andréa Mara | |
| dc.contributor.author | Lana, Marta de | |
| dc.date.accessioned | 2012-09-20T17:06:47Z | |
| dc.date.available | 2012-09-20T17:06:47Z | |
| dc.date.issued | 2006 | |
| dc.description.abstract | Herein, we have analyzed major biological properties following dual-clone Trypanosoma cruzi infections in BALB/c mice. Eight T. cruzi clonal stocks, two of each principal genotype, including genotype 19 and 20 (T. cruzi I), hybrid genotype 39 (T. cruzi) and 32 (T. cruzi II) were combined into 24 diVerent dual-clone infections. Special attention was given to characterize biological parameters assayed including: prepatent period, patent period, maximum of parasitemia, day of maximum parasitemia, area under the parasitemia curve, infectivity, mortality, and hemoculture positivity. Our Wndings clearly demonstrated that features resultant of dual-clone infections of T. cruzi clonal stocks did not display either the characteristics of the corresponding monoclonal infections or the theoretical mixture based on the respective monoclonal infections. SigniWcant changes in the expected values were observed in 4.2–79.2% of the mixtures considering the eight biological parameters studied. A lower frequency of signiWcant diVerences was found for mixtures composed by phylogenetically distant clonal stocks. Altogether, our data support our hypothesis that mixed T. cruzi infections have a great impact on the biological properties of the parasite in the host and re-emphasizes the importance of considering the possible occurrence of natural mixed infections in humans and their consequences on the biological aspects of ongoing Chagas’ disease. | pt_BR |
| dc.identifier.citation | MARTINS, H. R. et al. Trypanosoma cruzi : impact of dual-clone infections on parasite biological properties in BALB/c mice. Experimental Parasitology, v. 112, n.4, p. 237-246, abr. 2006. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0014489405002894>. Acesso em: 20 set. 2012. | pt_BR |
| dc.identifier.issn | 00144894 | |
| dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/1411 | |
| dc.language.iso | en_US | pt_BR |
| dc.rights.license | O periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281990662321. | |
| dc.title | Trypanosoma cruzi : impact of dual-clone infections on parasite biological properties in BALB/c mice. | pt_BR |
| dc.type | Artigo publicado em periodico | pt_BR |