Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.

Simple item page
dc.contributor.authorSantos, Robson Augusto Souza dos
dc.contributor.authorSilva, Ana Cristina Simões e
dc.contributor.authorMaric, Christine
dc.contributor.authorRabelo, Denise Maria Rover da Silva
dc.contributor.authorMachado, Raquel do Pilar
dc.contributor.authorBuhr, Insa de
dc.contributor.authorWalther, Silvia Heringer
dc.contributor.authorPinheiro, Sérgio Veloso Brant
dc.contributor.authorLopes, Miriam Teresa Paz
dc.contributor.authorBader, Michael
dc.contributor.authorMendes, Elizabeth Pereira
dc.contributor.authorLemos, Virgina Soares
dc.contributor.authorSantos, Maria José Campagnole dos
dc.contributor.authorSchultheiss, Heinz-Peter
dc.contributor.authorSpeth, Robert
dc.contributor.authorWalther, Thomas
dc.date.accessioned2017-04-27T13:01:49Z
dc.date.available2017-04-27T13:01:49Z
dc.date.issued2003
dc.description.abstractThe renin–angiotensin system plays a critical role in blood pressure control and body fluid and electrolyte homeostasis. Besides angiotensin (Ang) II, other Ang peptides, such as Ang III [Ang-(2–8)], Ang IV [Ang-(3–8)], and Ang-(1–7) may also have important biological activities. Ang-(1–7) has become an angiotensin of interest in the past few years, because its cardiovascular and baroreflex actions counteract those of Ang II. Unique angiotensin-binding sites specific for this heptapeptide and studies with a selective Ang-(1–7) antagonist indicated the existence of a distinct Ang-(1–7) receptor. We demonstrate that genetic deletion of the G proteincoupled receptor encoded by the Mas protooncogene abolishes the binding of Ang-(1–7) to mouse kidneys. Accordingly, Mas-deficient mice completely lack the antidiuretic action of Ang-(1–7) after an acute water load. Ang-(1–7) binds to Mas-transfected cells and elicits arachidonic acid release. Furthermore, Mas-deficient aortas lose their Ang-(1–7)-induced relaxation response. Collectively, these findings identify Mas as a functional receptor for Ang-(1–7) and provide a clear molecular basis for the physiological actions of this biologically active peptide.pt_BR
dc.identifier.citationSANTOS, R. A. S. et al. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proceedings National Academy Science, v. 100, n.14, p. 8258-8263, 2003. Disponível em: <http://www.pnas.org/content/100/14/8258.long>. Acesso em: 23 fev. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1073/pnas.1432869100
dc.identifier.issn1091-6490
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/7646
dc.identifier.uri2http://www.pnas.org/content/100/14/8258.longpt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectBindingpt_BR
dc.subjectMas protooncogenept_BR
dc.subjectRenin angiotensin systempt_BR
dc.titleAngiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.pt_BR
dc.typeArtigo publicado em periodicopt_BR
Files
Collections
DECBI - Artigos publicados em periódicos