Methotrexate locally released from poly (caprolactone) implants : inhibition of the inflammatory angiogenesis response in a murine sponge model and the absence of systemic toxicity.

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dc.contributor.authorOliveira, Leandro Gonzaga de
dc.contributor.authorFigueiredo, Letícia Aparecida
dc.contributor.authorCunha, Gabriella Maria Fernandes
dc.contributor.authorOliveira, Laser Antônio Machado de
dc.contributor.authorMiranda, Marina Barcelos de
dc.contributor.authorSilva, Gisele Rodrigues da
dc.contributor.authorMoura, Sandra Aparecida Lima de
dc.date.accessioned2016-07-25T16:21:12Z
dc.date.available2016-07-25T16:21:12Z
dc.date.issued2015
dc.description.abstractIn this study, the methotrexate (MTX) was incorporated into the poly(-caprolactone) (PCL) to design implants (MTX PCL implants) aiming the local treatment of inflammatory angiogenesis diseases without causing systemic side effects. Sponges were inserted into the subcutaneous tissue of mice as a framework for fibrovascular tissue growth. After 4 days, MTX PCL implants were also introduced, and anti-inflammatory, antiangiogenic, and antifibrogenic activities of the MTX were determined. MTX reduced the vascularization (hemoglobin content), the neutrophil, and monocyte/macrophage infiltration (MPO and NAG activities, respectively), and the collagen deposition in sponges. MTX reduced tumor necrosis factor-_ and IL-6 levels, demonstrating its local antiangiogenic and anti-inflammatory effects. Furthermore, hepatotoxicity, nephrotoxicity, and myelotoxicity, which could be induced by the drug, were evaluated. However, MTX did not promote toxicity to these organs, as the levels of AST and ALT (hepatic markers) and creatinine and urea (renal markers) were not increased, and the complete blood count was not decreased. In conclusion, MTX PCL implants demonstrated to be effective in regulating the components of the inflammatory angiogenesis locally established, and presented an acceptable safety profile. C _ 2015Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci.pt_BR
dc.identifier.citationOLIVEIRA, L. G. de et al. Methotrexate locally released from poly (caprolactone) implants : inhibition of the inflammatory angiogenesis response in a murine sponge model and the absence of systemic toxicity. Journal of Pharmaceutical Sciences, v. 104, p. 3731-3742, 2015. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0022354916301599>. Acesso em: 16 jun. 2016.pt_BR
dc.identifier.doihttps://doi.org/10.1002/jps.24569
dc.identifier.issn1520-6017
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/6627
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseO periódico Journal of Pharmaceutical Sciences concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3897040971930.pt_BR
dc.subjectBiodegradable polymerspt_BR
dc.subjectBiomaterialspt_BR
dc.subjectControlled release/deliverypt_BR
dc.subjectTargeted drug deliverypt_BR
dc.subjectPolymeric drug delivery systemspt_BR
dc.titleMethotrexate locally released from poly (caprolactone) implants : inhibition of the inflammatory angiogenesis response in a murine sponge model and the absence of systemic toxicity.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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