Cardiac and renal effects induced by different exercise workloads in renovascular hypertensive rats.
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Date
2011
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Abstract
We examined the effect of exercise training (Ex) without (Ex 0%) or with a 3% workload (Ex 3%) on different cardiac and renal
parameters in renovascular hypertensive (2K1C) male Fisher rats weighing 150-200 g. Ex was performed for 5 weeks, 1 h/day,
5 days/week. Ex 0% or Ex 3% induced similar attenuation of baseline mean arterial pressure (MAP, 119 ± 5 mmHg in 2K1C Ex
0%, N = 6, and 118 ± 5 mmHg in 2K1C Ex 3%, N = 11, vs 99 ± 4 mmHg in sham sedentary (Sham Sed) controls, N = 10) and
heart rate (HR, bpm) (383 ± 13 in 2K1C Ex 0%, N = 6, and 390 ± 14 in 2K1C Ex 3%, N = 11 vs 371 ± 11 in Sham Sed, N = 10).
Ex 0%, but not Ex 3%, improved baroreflex bradycardia (0.26 ± 0.06 ms/mmHg, N = 6, vs 0.09 ± 0.03 ms/mmHg in 2K1C Sed,
N = 11). Morphometric evaluation suggested concentric left ventricle hypertrophy in sedentary 2K1C rats. Ex 0% prevented
concentric cardiac hypertrophy, increased cardiomyocyte diameter and decreased cardiac vasculature thickness in 2K1C rats. In
contrast, in 2K1C, Ex 3% reduced the concentric remodeling and prevented the increase in cardiac vasculature wall thickness,
decreased the cardiomyocyte diameter and increased collagen deposition. Renal morphometric analysis showed that Ex 3%
induced an increase in vasculature wall thickness and collagen deposition in the left kidney of 2K1C rats. These data suggest
that Ex 0% has more beneficial effects than Ex 3% in renovascular hypertensive rats.
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Keywords
Cardiac and renal remodeling, Baroreflex bradycardia, Renovascular hypertension
Citation
SOARES, E. R. et al. Cardiac and renal effects induced by different exercise workloads in renovascular hypertensive rats. Brazilian Journal of Medical and Biological Research, v. 44, p. 573-582, 2011. Disponível em: <http://www.scielo.br/pdf/bjmbr/v44n6/816.pdf>. Acesso em 21 out. 2015.