Iron overload potentiates diet-induced hypercholesterolemia and reduces liver ppar-α expression in hamsters.

Bonomo, Larissa de Freitas; Silva, Maísa; Oliveira, Riva de Paula; Silva, Marcelo Eustáquio; Pedrosa, Maria Lúcia

Iron overload potentiates diet-induced hypercholesterolemia and reduces liver ppar-α expression in hamsters.

Date

2012

Authors

Bonomo, Larissa de Freitas

Silva, Maísa

Oliveira, Riva de Paula

Silva, Marcelo Eustáquio

Pedrosa, Maria Lúcia

Abstract

Iron stores and lipids are related to the development of cardiovascular disease. Given that peroxisome proliferator-activated receptor alpha (PPAR-α) regulates important physiological processes that impact lipid and glucose homeostasis, we decided to investigate the effects of iron overload on serum lipids and the liver expression of PPAR-α, 3-hydroxy- 3-methylglutaryl coenzyme A reductase, and cholesterol 7α-hydroxylase. Hamsters were divided into four groups. The standard group (S) was fed the AIN-93M diet, the SI group was fed the diet and iron injections, the hypercholesterolemic group (H) was fed a standard diet containing cholesterol, and the HI group was fed a high-cholesterol diet and iron injections. Serum cholesterol in the HI group was higher than in the H group. Gene expression analysis of PPAR-α showed that the HI group had a lower PPAR-α expression than H. These data show that iron, when associated with a high-fat diet, can cause increased serum cholesterol levels, possibly due to a reduction in PPAR- α expression.

Keywords

Cholesterol

Citation

BONOMO, L. de F. et al. Iron overload potentiates diet-induced hypercholesterolemia and reduces liver ppar-α expression in hamsters. Journal of Biochemical and Molecular Toxicology, v. 26, p. 224-229, 2012. Disponível em: <https://goo.gl/n6F8PI>. Acesso em: 23 fev. 2017.