Influence of clinical status and parasite load on Erythropoiesis and Leucopoiesis in dogs naturally infected with Leishmania (Leishmania) chagasi.

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dc.contributor.authorAbreu, Raquel Trópia de
dc.contributor.authorCarvalho, Maria das Graças
dc.contributor.authorCarneiro, Cláudia Martins
dc.contributor.authorGiunchetti, Rodolfo Cordeiro
dc.contributor.authorCarvalho, Andréa Teixeira de
dc.contributor.authorMartins Filho, Olindo Assis
dc.contributor.authorVital, Wendel Coura
dc.contributor.authorOliveira, Rodrigo Corrêa de
dc.contributor.authorReis, Alexandre Barbosa
dc.date.accessioned2012-07-04T14:40:26Z
dc.date.available2012-07-04T14:40:26Z
dc.date.issued2011
dc.description.abstractBackground: The bone marrow is considered to be an important storage of parasites in Leishmania -infected dogs, although little is known about cellular genesis in this organ during canine visceral leishmaniasis (CVL). Methodology/Principal Findings:The aim of the present study was to evaluate changes in erythropoiesis and leucopoiesis in bone marrow aspirates from dogs naturally infected with Leishmania chagasi and presenting different clinical statuses and bone marrow parasite densities. The evolution of CVL from asymptomatic to symptomatic status was accompanied by increasing parasite density in the bone marrow. The impact of bone marrow parasite density on cellularity was similar in dogs at different clinical stages, with animals in the high parasite density group. Erythroid and eosinophilic hypoplasia, proliferation of neutrophilic precursor cells and significant increases in lymphocytes and plasma cell numbers were the major alterations observed. Differential bone marrow cell counts revealed increases in the myeloid:erythroid ratio associated to increased numbers of granulopoietic cells in the different clinical groups compared with non-infected dogs. Conclusions: Analysis of the data obtained indicated that the assessment of bone marrow constitutes an additional and useful tool by which to elaborate a prognosis for CVL.pt_BR
dc.identifier.citationABREU, R. T. de et al. Influence of clinical status and parasite load on Erythropoiesis and Leucopoiesis in dogs naturally infected with Leishmania (Leishmania) chagasi. Plos One, v. 6, n. 5, 2011. Disponível em: <https://journals.plos.org/plosone/article/authors?id=10.1371/journal.pone.0018873>. Acesso em: 04 jul. 2012.pt_BR
dc.identifier.issn19326203
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/957
dc.language.isoen_USpt_BR
dc.rights.licenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Fonte: o próprio artigo.
dc.titleInfluence of clinical status and parasite load on Erythropoiesis and Leucopoiesis in dogs naturally infected with Leishmania (Leishmania) chagasi.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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