An orally active angiotensin-(1–7) inclusion compound and exercisetraining produce similar cardiovascular effects in spontaneouslyhypertensive rats.

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dc.contributor.authorBertagnolli, Mariane
dc.contributor.authorCasali, Karina Rabello
dc.contributor.authorSousa, Frederico Barros de
dc.contributor.authorRigatto, Katya
dc.contributor.authorOliveira, Lenice Kappes Becker
dc.contributor.authorSantos, Sergio Henrique Sousa
dc.contributor.authorDias, Lucinara Dadda
dc.contributor.authorPinto, Graziela
dc.contributor.authorDartora, Daniela Ravizzoni
dc.contributor.authorSchaan, Beatriz D'Agord
dc.contributor.authorMilan, Ruben Dario Sinisterra
dc.contributor.authorIrigoyen, Maria Claudia
dc.contributor.authorSantos, Robson Augusto Souza dos
dc.date.accessioned2015-09-22T19:17:06Z
dc.date.available2015-09-22T19:17:06Z
dc.date.issued2014
dc.description.abstractLow angiotensin-(1–7) (Ang-(1–7)) concentration is observed in some cardiovascular diseases and exer-cise training seems to restore its concentration in the heart. Recently, a novel formulation of an orallyactive Ang-(1–7) included in hydroxy-propyl-beta-cyclodextrin (HPB-CD) was developed and chronicallyadministered in experimental models of cardiovascular diseases. The present study examined whetherchronic administration of HPB-CD/Ang-(1–7) produces beneficial cardiovascular effects in spontaneouslyhypertensive rats (SHR), as well as to compare the results obtained with those produced by exercisetraining. Male SHR (15-week old) were divided in control (tap water) or treated with HPB-CD/Ang-(1–7)(corresponding to 30 _g kg−1day−1of Ang-(1–7)) by gavage, concomitantly or not to exercise training(treadmill, 10 weeks). After chronic treatment, hemodynamic, morphometric and molecular analysis inthe heart were performed. Chronic HPB-CD/Ang-(1–7) decreased arterial blood pressure (BP) and heartrate in SHR. The inclusion compound significantly improved left ventricular (LV) end-diastolic pressure,restored the maximum and minimum derivatives (dP/dT) and decreased cardiac hypertrophy index inSHR. Chronic treatment improved autonomic control by attenuating sympathetic modulation on heartand vessels and the SAP variability, as well as increasing parasympathetic modulation and HR variability.Overall results were similar to those obtained with exercise training. These results show that chronictreatment with the HPB-CD/Ang-(1–7) inclusion compound produced beneficial effects in SHR resem-bling the ones produced by exercise training. This observation reinforces the potential cardiovasculartherapeutic effect of this novel peptide formulation.pt_BR
dc.identifier.citationBERTAGNOLLI, M. et al. An orally active angiotensin-(1–7) inclusion compound and exercise training produce similar cardiovascular effects in spontaneously hypertensive rats. Peptides, New York, v. 51, p. 65-73, 2014. Disponível em: <http://www.sciencedirect.com/science/article/pii/S019697811300377X>. Acesso em: 16 mar. 2015.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.peptides.2013.11.006
dc.identifier.issn0196-9781
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/5654
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Peptides concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3591321115084.pt_BR
dc.subjectHypertensionpt_BR
dc.subjectExercise trainingpt_BR
dc.subjectCardiac functionpt_BR
dc.subjectAutonomic controlpt_BR
dc.titleAn orally active angiotensin-(1–7) inclusion compound and exercisetraining produce similar cardiovascular effects in spontaneouslyhypertensive rats.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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