Combination therapy using nitro compounds improves the efficacy of experimental Chagas disease treatment.

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dc.contributor.authorMazzeti, Ana Lia
dc.contributor.authorGonçalves, Karolina Ribeiro
dc.contributor.authorMota, Suianne Letícia Antunes
dc.contributor.authorPereira, Dario Elias
dc.contributor.authorDiniz, Lívia de Figueiredo
dc.contributor.authorBahia, Maria Terezinha
dc.date.accessioned2023-05-03T20:45:51Z
dc.date.available2023-05-03T20:45:51Z
dc.date.issued2021pt_BR
dc.description.abstractDrug combinations have been evaluated for Chagas disease in an attempt to improve efficacy and safety. In this line, the objective of this work is to assess the effects of treatment with nitro drugs combinations using benznidazole (BZ) or nifurtimox (NFX) plus the sulfone metabolite of fexinidazole (fex-SFN) in vitro and in vivo on Trypanosoma cruzi infection. The in vitro interaction of fex-SFN and BZ or NFX against infected H9c2 cells by the Y strain was classi- fied as an additive (0.5⩾ΣFIC<4), suggesting the possibility of a dose reduction in the in vivo T. cruzi infection. Next, the effect of combining suboptimal doses was assessed in an acute model of murine T. cruzi infection. Drug combinations led to a faster suppression of parasit- emia than monotherapies. Also, the associations led to higher cure levels than those in the reference treatment BZ 100 mg day−1 (57.1%) (i.e. 83.3% with BZ/fex-SFN and 75% with NFX/fex-SFN). Importantly, toxic effects resulting from the associations were not observed, according to weight gain and hepatic enzyme levels in the serum of experimental animals. Taken together, this study is a starting point to explore the potential effects of nitro drugs combinations in preclinical models of kinetoplastid-related infections.pt_BR
dc.identifier.citationMAZZETI, A. L. et al. Combination therapy using nitro compounds improves the efficacy of experimental Chagas disease treatment. Parasitology, v. 148, p. 1320-1327, 2021. Disponível em: <https://www.cambridge.org/core/journals/parasitology/article/abs/combination-therapy-using-nitro-compounds-improves-the-efficacy-of-experimental-chagas-disease-treatment/4663987A4596FBE968EA04D2C0F14E06>. Acesso em: 11 out. 2022.pt_BR
dc.identifier.doihttps://doi.org/10.1017/S0031182021001001pt_BR
dc.identifier.issn1469-8161
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/16513
dc.identifier.uri2https://www.cambridge.org/core/journals/parasitology/article/abs/combination-therapy-using-nitro-compounds-improves-the-efficacy-of-experimental-chagas-disease-treatment/4663987A4596FBE968EA04D2C0F14E06pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectBenznidazolept_BR
dc.subjectTrypanosoma cruzipt_BR
dc.subjectChagas diseasept_BR
dc.subjectChemotherapypt_BR
dc.subjectCombinationpt_BR
dc.titleCombination therapy using nitro compounds improves the efficacy of experimental Chagas disease treatment.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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