Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects.
| dc.contributor.author | Carraro, Júlia Cristina Cardoso | |
| dc.contributor.author | Hermsdorff, Helen Hermana Miranda | |
| dc.contributor.author | Mansego, Maria Luisa | |
| dc.contributor.author | Zulet, Maria Angeles | |
| dc.contributor.author | Milagro, Fermín Ignacio | |
| dc.contributor.author | Bressan, Josefina | |
| dc.contributor.author | Martínez, J. Alfredo | |
| dc.date.accessioned | 2017-10-24T17:20:27Z | |
| dc.date.available | 2017-10-24T17:20:27Z | |
| dc.date.issued | 2016 | |
| dc.description.abstract | Background/Aim: This study hypothesized an association between healthy dietary patterns, hypermethylation of the tumor necrosis factor-α (TNF-α) promoter and decreased risk of metabolic changes. Methods: Forty normal-weight young women were involved in this crosssectional study. DNA was isolated from white blood cells, and CpG site methylation in TNF-α was analyzed by Sequenom EpiTyper. The quality of the diet was assessed by Healthy Eating Index (HEI-2005). Results: Contradicting our hypothesis, HEI-2005 score was negatively associated with CpG5 (r = –0.460, p = 0.003) and TNF-α total methylation (r = –0.355, p = 0.026). A higher intake of fruits was related to lower insulin, HOMA-IR, and TNF-α methylation. No other dietary pattern was related to TNF-α methylation. TNF-α total methylation correlated positively with systolic blood pressure (r = 0.323; p = 0.042) and CpG5 methylation with body mass index (r = 0.333, p = 0.036). Furthermore, fiber intake was negatively associated with the CpG5 (r = –0.324, p = 0.041) and TNF-α total methylation (r = –0.434, p = 0.005), whereas vitamin C intake was negatively associated with TNF-α total methylation (r = –0.411, p = 0.009). Intakes of apples and citrus fruits were negatively associated with TNF-α total methylation. Conclusion: A healthy dietary pattern and higher fruit intake (particularly apples and citrus fruits) were related to better glucose tolerance in healthy subjects, which could be mediated by lower TNF-α methylation. | pt_BR |
| dc.identifier.citation | CARRARO, J. C. C. et al. Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects. Journal of Nutrigenetics and Nutrigenomics, v. 9, p. 95-105, 2016. Disponível em: <https://www.karger.com/Article/Abstract/448101>. Acesso em: 29 ago. 2017. | pt_BR |
| dc.identifier.doi | https://doi.org/10.1159/000448101 | |
| dc.identifier.issn | 1661-6758 | |
| dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/9035 | |
| dc.identifier.uri2 | https://www.karger.com/Article/Abstract/448101 | pt_BR |
| dc.language.iso | en_US | pt_BR |
| dc.rights | aberto | pt_BR |
| dc.subject | Biomarker | pt_BR |
| dc.subject | Inflammation | pt_BR |
| dc.subject | Epigenetics | pt_BR |
| dc.subject | DNA methylation | pt_BR |
| dc.subject | Diet | pt_BR |
| dc.title | Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects. | pt_BR |
| dc.type | Artigo publicado em periodico | pt_BR |