Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia.

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dc.contributor.authorCangussu, Luiza Michelle
dc.contributor.authorCastro, Uberdan Guilherme Mendes de
dc.contributor.authorMachado, Raquel do Pilar
dc.contributor.authorSilva, Marcelo Eustáquio
dc.contributor.authorFerreira, Patrícia Maria
dc.contributor.authorSantos, Robson Augusto Souza dos
dc.contributor.authorSantos, Maria José Campagnole dos
dc.contributor.authorAlzamora, Andréia Carvalho
dc.date.accessioned2012-07-12T19:15:30Z
dc.date.available2012-07-12T19:15:30Z
dc.date.issued2009
dc.description.abstractIn the present study we evaluated the effect of caudal ventrolateral medulla (CVLM) microinjection of the main angiotensin (Ang) peptides, Ang II and Ang-(1-7), and their selective antagonists on baseline arterial pressure (AP) and on baroreceptor-mediated bradycardia in renovascular hypertensive rats (2K1C). Microinjection of Ang II and Ang-(1-7) into the CVLM of 2K1C rats produced similar decrease in AP as observed in Sham rats. In both Sham and 2K1C, the hypotensive effect of Ang II and Ang-(1-7) at the CVLM was blocked, for up to 30 min, by previous CVLM microinjection of the Ang II AT 1 receptor antagonist, Losartan, and Ang-(1-7) Mas antagonist, A-779, respectively. As expected, the baroreflex bradycardia was lower in 2K1C in comparison to Sham rats. CVLM microinjection of A-779 improved the sensitivity of baroreflex bradycardia in 2K1C hypertensive rats. In contrast, Losartan had no effect on the baroreflex bradycardia in either 2K1C or Sham rats. These results suggest that Ang-(1-7) at the CVLM may contribute to the low sensitivity of the baroreflex control of heart rate in renovascular hypertensive ratspt_BR
dc.identifier.citationCANGUSSU, L. M. et al. Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia. Peptides, v. 30, n. 10, p. 1921-1927, out. 2009. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0196978109002666>. Acesso em: 12 jul. 2012.pt_BR
dc.identifier.issn01969781
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/1105
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Peptides concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3285361083380.
dc.subjectCaudal ventrolateral medullapt_BR
dc.subjectBaroreflex control of heart ratept_BR
dc.subjectAngiotensin IIpt_BR
dc.titleAngiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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