Isotype patterns of immunoglobulins : hallmarks for clinical status and tissue parasite density in brazilian dogs naturally infected by Leishmania (Leishmania) chagasi.

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dc.contributor.authorReis, Alexandre Barbosa
dc.contributor.authorCarvalho, Andréa Teixeira de
dc.contributor.authorVale, André Macedo
dc.contributor.authorMarques, Marcos José
dc.contributor.authorGiunchetti, Rodolfo Cordeiro
dc.contributor.authorMayrink, Wilson
dc.contributor.authorGuerra, Luanda Liboreiro
dc.contributor.authorAndrade, Renata Aline de
dc.contributor.authorOliveira, Rodrigo Corrêa de
dc.contributor.authorMartins Filho, Olindo Assis
dc.date.accessioned2012-07-10T16:38:37Z
dc.date.available2012-07-10T16:38:37Z
dc.date.issued2006
dc.description.abstractThe role of anti-leishmanial immune response underlying the susceptibility/resistance during canine visceral leishmaniasis (CVL) has been recognized throughout ex vivo and in vitro investigations. Recently, we demonstrated that immunoglobulin levels (Igs), as well as the parasite load are relevant hallmarks of distinct clinical status of CVL. To further characterize and upgrade the background on this issue, herein, we have evaluated, inLeishmania ( Leishmania ) chagasinaturally infected dogs, the relationship between tissue parasitism (skin, bone marrow, spleen, liver and lymph node), the CVL clinical status (asymptomatic (AD), with no suggestive signs of the disease; oligosymptomatic (OD), with maximum three clinical signs—opaque bristles; localized alopecia and moderate loss of weight; symptomatic (SD), serologically positive with severe clinical signs of visceral leishmaniasis), and the humoral immunological profile of anti-Leishmania immunoglobulins (IgG, IgG1, IgG2, IgM, IgA and IgE). Our major statistically significant findings revealed distinct patterns of tissue parasite density within L. chagasi-infected dogs despite their clinical status, pointing out the spleen and skin as the most relevant sites of high parasitism during ongoing CVL. Parasite density of bone marrow and spleen were the most reliable parasitological markers to decode the clinical status of CVL. Moreover, the parasite density of bone marrow better correlates with most anti- Leishmania Igs reactivity. Additionally, a prognostic hallmark for canine visceral leishmaniasis was found, highlighting strong correlation between IgG1 and asymptomatic disease, but with IgA, IgE and IgG2 displaying better association with symptomatic disease. The new aspects of this study highlighted pioneer findings that correlated the degree of tissue parasite density (low (LP), medium (MP) and high (HP) parasitism) with distinct patterns of anti- Leishmania Igs reactivity. In this scope, our data re-enforce the anti- Leishmania IgG but with IgA reactivity as the better marker for overall tissue parasitism. The association between clinical status, Ig profile and the tissue parasitism support a novel investigation on the impact of humoral immune response and susceptibility/resistance mechanism during ongoing CVLpt_BR
dc.identifier.citationREIS, A. B. et al. Isotype patterns of immunoglobulins : hallmarks for clinical status and tissue parasite density in brazilian dogs naturally infected by Leishmania (Leishmania) chagasi. Veterinary Immunology and Immunopathology, v. 112, n. 3-4, p. 102-116, ago. 2006. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0165242706000444>. Acesso em: 10 jul. 2010.pt_BR
dc.identifier.issn01652427
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/1056
dc.rights.licenseO periódico Veterinary Immunology and Immunopathology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3291410158044.
dc.subjectCanine visceral leishmaniasispt_BR
dc.subjectClinical formspt_BR
dc.subjectTissue parasitismpt_BR
dc.subjectImmunoglobulin profilept_BR
dc.subjectLeishmania chagasipt_BR
dc.titleIsotype patterns of immunoglobulins : hallmarks for clinical status and tissue parasite density in brazilian dogs naturally infected by Leishmania (Leishmania) chagasi.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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