Biological screening of extracts of Brazilian Asteraceae plants.

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dc.contributor.authorCarvalho, Cintia Cristina de
dc.contributor.authorMachado, Kamilla Nunes
dc.contributor.authorFerreira, Paulo Michel Pinheiro
dc.contributor.authorPessoa, Cláudia
dc.contributor.authorFonseca, Thaisa Helena Silva
dc.contributor.authorGomes, Maria Aparecida
dc.contributor.authorNascimento, Andréa Mendes do
dc.date.accessioned2015-04-01T17:29:37Z
dc.date.available2015-04-01T17:29:37Z
dc.date.issued2013
dc.description.abstractNatural products are a very productive source of leads for the development of medicines. Seven Brazilian Asteraceae adult plants were randomly chosen. The current study was designed to evaluate the antiprotozoal and cytotoxic activities in vitro of 21 extracts obtained. Phytochemical properties of the most active extracts also were checked. Cytotoxic activity was evaluated by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) method against human tumor cell lines (HCT-116, OVCAR 8 and SF-295). The antiprotozoal activity was evaluated against Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia. None of the extracts showed antiprotozoal activity. However, 76% of the extracts displayed moderate to high in vitro cytotoxic activities against human cancer cell which suggests that they are a promising source of anticancer compound, since none of the extracts showed hemolytic activity. Terpenoids, flavonoids, saponins, tannins, besides other compound classes, were identified and may be responsible for their antitumor activity. Cytotoxic assays indicate the anticancer potential of Asteraceae species from Brazil.pt_BR
dc.identifier.citationCARVALHO, C. C. de et al. Biological screening of extracts of Brazilian Asteraceae plants. African Journal of Pharmacy and Pharmacology, v. 7, p. 2000-2005, 2013. Disponível em: <http://www.academicjournals.org/article/article1380791717_Carvalho%20et%20al.pdf>. Acesso em: 02 fev. 2015.pt_BR
dc.identifier.doihttps://doi.org/10.5897/AJPP2013.3598
dc.identifier.issn1996-0816
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/4912
dc.language.isoen_USpt_BR
dc.rights.licenseThis article is published under the terms of the Creative Commons Attribution License 4.0 that allows copy and redistribute the material in any medium or format. Fonte: African Journal of Pharmacy and Pharmacology <https://academicjournals.org/journal/AJPP/article-abstract/AB1466F27905>. Acesso em: 25 fev. 2014.pt_BR
dc.subjectDrug prospectingpt_BR
dc.subjectAntiprotozoal agentspt_BR
dc.subjectCytotoxicitypt_BR
dc.subjectDrug screening assayspt_BR
dc.subjectBrazilian plantpt_BR
dc.titleBiological screening of extracts of Brazilian Asteraceae plants.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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