Antitumor activity of Pd(II) complexes with N,S or O,S coordination modes of acylthiourea ligands.

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dc.contributor.authorStevens, Ana María Plutín
dc.contributor.authorRamos Cairo, Raúl
dc.contributor.authorMocelo, Raúl
dc.contributor.authorAlvarez Hernández, Anislay
dc.contributor.authorCastellano, Eduardo Ernesto
dc.contributor.authorCominetti, Márcia Regina
dc.contributor.authorOliveira, Katia Mara de
dc.contributor.authorOliveira, Tamires Donizeth de
dc.contributor.authorSilva, Thales E. M.
dc.contributor.authorOliveira, Rodrigo Corrêa de
dc.contributor.authorBatista, Alzir Azevedo
dc.date.accessioned2021-12-16T15:30:03Z
dc.date.available2021-12-16T15:30:03Z
dc.date.issued2020pt_BR
dc.description.abstractSeven new complexes (1–7) of Pd(II) with N-alkyl- and N,N-dialkyl-N0 -acylthioureas were prepared and characterized by elemental analysis and spectroscopic techniques. The crystal structures of the coordination compounds [PdCl(PPh3)(5-cloropiridyl-N0 -benzoylthioureato-k2 N,S)] (2), cis-[Pd(PPh3)2 (N-morpholyn-N0 -benzoylthioureato-k2 O,S)]PF6 (4) and cis-[Pd(PPh3)2(N,N-diphenyl-N0 -thiophenylth ioureato-k2 O,S)]PF6 (7) were determined by X-ray crystallography. The present study reports on an inter esting contribution on the chemistry of Pd(II)/acylthiourea complexes, where the use of monosubstituted acylthiourea conducts to formation of neutral complexes with general formula [Pd(Cl)(PPh3) (acylthiourea)], with a N,S-coordination mode. On the other hand, cationic complexes with formula [Pd (PPh3)2(acylthiourea)]+ , with O,S bidentately coordinated to the metal, are obtained by using a disubsti tuted acylthiourea derivative. The antitumor activity of the N-alkyl- and N,N-dialkyl-N0 -acylthiourea ligands and their palladium (II) complexes with synthesized triphenylphosphine were evaluated against the growth of the DU-145 tumor cells (prostate cancer cells), (MDA-MB-231 (breast cancer cells), L929 (healthy mouse cells). The ligands are not cytotoxic, but the complexes showed good cytotoxicity against the tumor cells tested in this work, and were even better, when compared to the IC50 reported for the cis platin. The complexes showed better activity results in MDA-MB-231 tumor cells, than for the DU-145 tumor cells. Complexes 1 and 6 showed high cytotoxic activity at low micromolar concentrations (IC50 = 1.93 ± 0.45, 0.62 ± 0.08 lM) against MDA-MB-231 (human breast cancer cells). This result indicated that the binding of the ligands to the metal center increases their antitumor activity.pt_BR
dc.identifier.citationSTEVENS, A. M. P. et al. Antitumor activity of Pd(II) complexes with N,S or O,S coordination modes of acylthiourea ligands. Polyhedron, v. 184, artigo 114543, 2020. Disponível em: <https://www.sciencedirect.com/science/article/abs/pii/S027753872030200X?via%3Dihub>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.poly.2020.114543pt_BR
dc.identifier.issn0277-5387
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/14248
dc.identifier.uri2https://www.sciencedirect.com/science/article/abs/pii/S027753872030200X?via%3Dihubpt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectCrystal structurept_BR
dc.subjectCytotoxicitypt_BR
dc.titleAntitumor activity of Pd(II) complexes with N,S or O,S coordination modes of acylthiourea ligands.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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