Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.

Simple item page
dc.contributor.authorTullet, Jennifer M. A.
dc.contributor.authorHertweck, Maren
dc.contributor.authorAn, Jae Hyung
dc.contributor.authorBaker, Joseph
dc.contributor.authorHwang, Ji Yun
dc.contributor.authorLiu, Shu
dc.contributor.authorOliveira, Riva de Paula
dc.contributor.authorBaumeister, Ralf
dc.contributor.authorBlackwell, T. Keith
dc.date.accessioned2015-03-31T21:43:06Z
dc.date.available2015-03-31T21:43:06Z
dc.date.issued2008
dc.description.abstractInsulin/IGF-1-like signaling (IIS) is central to growth and metabolism and has a conserved role in aging. In C. elegans, reductions in IIS increase stress resistance and longevity, effects that require the IISinhibited FOXO protein DAF-16. The C. elegans transcription factor SKN-1 also defends against oxidative stress bymobilizing the conserved phase 2 detoxification response. Herewe showthat IIS not only opposes DAF-16 but also directly inhibits SKN-1 in parallel. The IIS kinases AKT-1, -2, and SGK-1 phosphorylate SKN-1, and reduced IIS leads to constitutive SKN-1 nuclear accumulation in the intestine and SKN-1 target gene activation. SKN-1 contributes to the increased stress tolerance and longevity resulting from reduced IIS and delays aging when expressed transgenically. Furthermore, SKN-1 that is constitutively active increases life span independently of DAF-16. Our findings indicate that the transcription network regulated by SKN-1 promotes longevity and is an important direct target of IIS.pt_BR
dc.identifier.citationTULLET, J. M. A. et al. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell, v. 132, p. 1025-1038, 2008. Disponível em: <http://www.sciencedirect.com/science/article/pii/S009286740800130X>. Acesso em: 15 out. 2014.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.cell.2008.01.030
dc.identifier.issn0092-8674
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/4847
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Cell concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3493711392245.pt_BR
dc.titleDirect inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.pt_BR
dc.typeArtigo publicado em periodicopt_BR
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ARTIGO_DirectInhibitionLongevity.pdf
Size:
1.76 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.57 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
DEBIO - Artigos publicados em periódicos