Clustered cardiovascular risk factors are associated with inflammatory markers in adolescents.
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Date
2017
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Abstract
Background: Clusters of cardiovascular risk (CVR) factors are
associated with an increased risk of developing cardiovascular
diseases (CVDs). This cross-sectional study assessed the
associations between classic CVR factor clusters and inflammatory
markers in Brazilian adolescents. Methods: Measurements
included anthropometric, clinical and biochemical
parameters and selected inflammatory markers in 487 adolescents
(236 boys/251 girls; 12.06 ± 1.41 years). Results:
After stratifying the population by gender and adjusting for
potential confounding variables, principal component analysis
was performed and it produced 5 independent components
in both genders: adiposity, glucose metabolism, blood
pressure, high-density lipoprotein (HDL)/triacylglycerols
(TG), and cholesterol/low-density lipoprotein. Glucose metabolism
was inversely associated with interleukin-1β (IL-1β)
in both genders ( r = –0.026; r = –0.021); blood pressure was
inversely associated with tumor necrosis factor alpha (TNF-α)
in girls ( r = –0.046); HDL/TG was positively associated with
interleukin-6 in girls ( r = 0.012), with IL-1β ( r = 0.010) TNF-α ( r = 0.045) in boys, and inversely associated with adiponectin
in both genders ( r = –0.015; r = –0.013). Conclusion: The results
suggest that lipid metabolism alterations, as potential
early events in the development of CVDs, have a strong link
to the inflammatory process, in contrast to other clusters of
risk factors.
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Keywords
Cytokines, Cardiovascular disease - risk factors, Principal components analysis
Citation
SILVA, C. T. et al. Clustered cardiovascular risk factors are associated with inflammatory markers in adolescents. Annals of Nutrition and Metabolism, v. 70, p. 259-267, 2017. Disponível em: <https://www.karger.com/Article/FullText/458767>. Acesso em: 29 ago. 2017.