Evaluation of anti-candida albicans activity and release of ketoconazole in PMMA-G-PEG 4000 films.
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Date
2022
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Abstract
Modified release systems depend on the selection of an appropriate agent capable of
controlling the release of the drug, sustaining the therapeutic action over time, and/or releasing
the drug at the level of a particular tissue or target organ. Polyethylene glycol 4000 (PEG 4000)
is commonly employed in drug release formulations while polymethyl methacrylate (PMMA) is
non-toxic and has a good solubility in organic solvents. This study aimed at the incorporation
of ketoconazole in PMMA-g-PEG 4000 and its derivatives, thus evaluating its release profile and
anti-Candida albicans and cytotoxic activities. Ketoconazole was characterized and incorporated into
the copolymers. The ketoconazole incorporated in the copolymer and its derivatives showed an
immediate release profile. All copolymers with ketoconazole showed activity against Candida albicans
and were non-toxic to human cells in the entire concentration tested.
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REYNALDO, J. R. et al. Evaluation of anti-candida albicans activity and release of ketoconazole in PMMA-G-PEG 4000 films. International Journal of Molecular Sciences, v. 23, n. 18, artigo 10775, 2022. Disponível em: <https://www.mdpi.com/1422-0067/23/18/10775>. Acesso em: 06 jul. 2023.