"Half-sandwich"/RuII anticancer complexes containing triphenylphosphine and p-substituted benzoic acids.

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dc.contributor.authorAraujo Neto, João Honorato de
dc.contributor.authorOliveira, Katia Mara de
dc.contributor.authorLeite, Celisnolia M.
dc.contributor.authorColina Vegas, Legna Andreina
dc.contributor.authorNóbrega, Joaquim de Araújo
dc.contributor.authorCastellano, Eduardo Ernesto
dc.contributor.authorEllena, Javier Alcides
dc.contributor.authorCorrea, Rodrigo de Souza
dc.contributor.authorBatista, Alzir Azevedo
dc.date.accessioned2021-12-16T15:22:38Z
dc.date.available2021-12-16T15:22:38Z
dc.date.issued2020pt_BR
dc.description.abstractMononuclear and binuclear RuII/arene/triphenylphosphine complexes with p-substituted benzoic acid derivatives were prepared and characterized. These monocationic complexes of type [Ru(η6 -p-cymene)(PPh3)L] (L = benzoic acid (1), p-hydroxybenzoic acid (2), p-nitrobenzoic acid (3) and terephthalic acid (4)) were characterized using various techniques, such as nuclear magnetic resonance (NMR) and matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry, and the crystal structure of 1, 3 and 4 were determined by X-ray diffraction analysis. The cytotoxicity of the complexes was evaluated, in vitro, against tumorigenic [MDA-MB-231, MCF-7 (breast), A549 (lung) and DU-145 (prostate)] and non-tumorigenic [MCF-10A (breast), MRC-5 (lung) and PNT-2 (prostate)] cells. The binuclear complex (4) was inactive due to its low solubility. Complexes 1, 2 and 3 showed similar cytotoxicity, however, complex 1 presented better selectivity index against MDA-MB-231 than compounds 2 and 3. Cellular ruthenium absorption was explored by inductively coupled plasma mass spectrometry (ICP-MS) analyzing the whole cells and the culture medium. Complementary studies showed that complex 1 inhibited colony formation, induced morphology changes in cells and promoted cell cycle arrest in the Sub-G1 phase for the MDA-MB-231 cells.pt_BR
dc.identifier.citationARAÚJO NETO, J. H. de et al. "Half-sandwich"/RuII anticancer complexes containing triphenylphosphine and p-substituted benzoic acids. Journal of the Brazilian Chemical Society, v. 31, p. 2237-2249, 2020. Disponível em: <https://www.scielo.br/j/jbchs/a/qtVP9v3z5JxyJHY6HYKXW4s/abstract/?lang=en>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.doihttps://doi.org/10.21577/0103-5053.20200076pt_BR
dc.identifier.issn1678-4790
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/14247
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o PDF do artigo.pt_BR
dc.subjectPiano-stool RuII complexespt_BR
dc.subjectBenzoic acid analogspt_BR
dc.subjectCellular uptakept_BR
dc.title"Half-sandwich"/RuII anticancer complexes containing triphenylphosphine and p-substituted benzoic acids.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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